Journal Article Review Epublish 2 citations
PubMed: 39519223 DOI: 10.3390/ijms252111670
Psoriasis and Seasonality: Exploring the Genetic and Epigenetic Interactions.
Int J Mol Sci 25(21)
Authors: Michał Niedźwiedź, Małgorzata Skibińska, Magdalena Ciążyńska, Marcin Noweta, Agnieszka Czerwińska, Janusz Krzyścin, Joanna Narbutt, Aleksandra Lesiak
Affiliations
- Department of Dermatology, Paediatric Dermatology and Oncology, Medical University of Lodz, 90-419 Lodz, Poland.
- International Doctoral School, Medical University of Lodz, 90-419 Lodz, Poland.
- Institute of Geophysics, Polish Academy of Sciences, 01-452 Warsaw, Poland.
- Laboratory of Autoinflammatory, Genetic and Rare Skin Disorders, Medical University of Lodz, 90-419 Lodz, Poland.
Abstract
Psoriasis is a multifactorial, chronic, and inflammatory disease that severely impacts patients' quality of life. The disease is caused by genetic irregularities affected by epigenetic and environmental factors. Some of these factors may include seasonal changes, such as solar radiation, air pollution, and humidity, and changes in circadian rhythm, especially in the temporal and polar zones. Thus, some psoriasis patients report seasonal variability of symptoms. Through a comprehensive review, we aim to delve deeper into the intricate interplay between seasonality, environmental factors, and the genetic and epigenetic landscape of psoriasis. By elucidating these complex relationships, we strive to provide insights that may inform targeted interventions and personalized management strategies for individuals living with psoriasis.
MeSH
Genetics, Circadian Rhythm, Air Pollution, Humidity, Psoriasis