Journal Article Epublish
PubMed: 39519593 DOI: 10.3390/nu16213760
Protective Effects of Plum on Liver and Gut Injury in Metabolic Dysfunction-Associated Fatty Liver Disease.
Nutrients 16(21)
Authors: Ji-Su Kim, Sun-Mee Hong, Do-Kyun Kim, Young-Eun Cho
Affiliations
- Department of Food and Nutrition, Andong National University, Andong 36729, Republic of Korea.
- Department of Technology Development, Marine Industry Research Institute for East Sea Rim, Uljin 36315, Republic of Korea.
- Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea.
Abstract
Metabolic dysfunction-associated fatty liver disease (MASLD), a persistent liver condition associated with metabolic syndrome, is primarily caused by excessive fructose intake and a typical Western diet. Because there is currently only one approved treatment, lifestyle and dietary interventions are crucial. This study assessed the effects of dietary intervention involving freeze-dried plum (FDP), a natural source of antioxidants containing diverse polyphenols. This study aimed to assess its potential as a protective agent against the gut-liver axis and its therapeutic effects on liver injury and gut permeability issues associated with MASLD. We indicate that 10% FDP intake restored gut barrier proteins and reduced serum endotoxin levels in the MASLD mouse models. Additionally, 10% FDP intake significantly reduced hepatic oxidative stress, lipid metabolism, and fibrosis marker levels. Interestingly, FDP intake significantly reduced the levels of inflammatory cytokine tumor necrosis factor-α and markers of liver damage, such as serum alanine aminotransferase/aspartate aminotransferase and hepatic triglycerides. These results highlight that dietary intervention with FDP that acts as a natural antioxidant may be a significant protective and therapeutic agent against liver and gut damage caused by MASLD.
MeSH
Liver Diseases, Serum, Aspartate Aminotransferases, Transaminases, Liver, Diet, Food, Antioxidants, Therapeutics, Fatty Liver