Journal Article Review Epublish 3 citations
PubMed: 39544947 DOI: 10.3389/fimmu.2024.1487576
The role of inflammatory response and metabolic reprogramming in sepsis-associated acute kidney injury: mechanistic insights and therapeutic potential.
Front Immunol 15:1487576
Authors: An-Bu Liu, Bin Tan, Ping Yang, Na Tian, Jin-Kui Li, Si-Cong Wang, Li-Shan Yang, Lei Ma, Jun-Fei Zhang
Affiliations
- Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, General Hospital of Ningxia Medical University, Yinchuan, China.
- Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
- Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. School of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
- Department of Emergency Medical, Yanchi County People's Hospital, Wuzhong, Ningxia, China.
Abstract
Sepsis represents a severe condition characterized by organ dysfunction resulting from a dysregulated host response to infection. Among the organs affected, the kidneys are particularly vulnerable, with significant functional impairment that markedly elevates mortality rates. Previous researches have highlighted that both inflammatory response dysregulation and metabolic reprogramming are crucial in the onset and progression of sepsis associated acute kidney injury (SA-AKI), making these processes potential targets for innovative therapies. This study aims to elucidate the pathophysiological mechanisms of renal injury in sepsis by perspective of inflammatory response dysregulation, with particular emphasis on pyroptosis, necroptosis, autophagy, and ferroptosis. Furthermore, it will incorporate insights into metabolic reprogramming to provide a detailed analysis of the mechanisms driving SA-AKI and explore potential targeted therapeutic strategies, providing solid theoretical framework for the development of targeted therapies for SA-AKI.
MeSH
Kidney, Immune System Diseases, Sepsis, Therapeutics, Acute Kidney Injury
Cited by
- Insights from integrative spatial transcriptomics in sepsis-associated acute kidney injury. Nat Rev Nephrol, 2026
- Programmed cell death markers in COVID-19 survivors with and without sepsis. Front Immunol, 2025
- Dasatinib and Quercetin Combination Increased Kidney Damage in Acute Folic Acid-Induced Experimental Nephropathy. Pharmaceuticals (Basel), 2025
- Metabolomics- and proteomics-based multi-omics integration reveals early metabolite alterations in sepsis-associated acute kidney injury. BMC Med, 2025