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Systematic Review Journal Article Meta-Analysis Epublish 6 citations

PubMed: 39563236 DOI: 10.1186/s12879-024-10161-1

Maternal COVID-19 infection and risk of respiratory distress syndrome among newborns: a systematic review and meta-analysis.

BMC Infect Dis 24(1):1318

Authors: Muhammed Shabil, Shilpa Gaidhane, Suhas Ballal, Sanjay Kumar, Mahakshit Bhat, Shilpa Sharma, M Ravi Kumar, Sarvesh Rustagi, Mahalaqua Nazli Khatib, Nishant Rai, Mohammed Garout, Nabiha A Bouafia, Amer Alshengeti, Hayam A Alrasheed, Nawal A Al Kaabi, Mubarak Alfaresi, Ali Hazazi, Ali A Rabaan, Sanjit Sah, Sorabh Lakhanpal, Ganesh Bushi, Laksmi Thangavelu, Nagavalli Chilakam, Sakshi Pandey, Manvinder Brar, Rachana Mehta, Ashok Kumar Balaraman, Rukshar Syed, Gajendra Sharma

Affiliations

  • University Center for Research and Development, Chandigarh University, Mohali, Punjab, India.
  • Medical Laboratories Techniques Department, AL-Mustaqbal University, Hillah, Babil, 51001, Iraq.
  • One Health Centre, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education, Wardha, India.
  • Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
  • Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan, 303012, India.
  • Department of Medicine, National Institute of Medical Sciences, NIMS University Rajasthan, Jaipur, India.
  • Chandigarh Pharmacy College, Chandigarh Group of Colleges-Jhanjeri, Mohali, 140307, Punjab, India.
  • Department of Chemistry, Raghu Engineering College, Visakhapatnam, 531162, Andhra Pradesh, India.
  • School of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, India.
  • Division of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education, Wardha, India.
  • Department of Biotechnology, Graphic Era (Deemed to be University, Clement Town Dehradun, Bharu, 248002, India.
  • Department of Allied Sciences, Graphic Era Hill University Clement Town Dehradun, Bharu, 248002, India.
  • Department of Community Medicine and Health Care for Pilgrims, Faculty of Medicine, Umm Al-Qura University, Makkah, 21955, Saudi Arabia.
  • Infection prevention and control centre of Excellence, Prince Sultan Medical Military City, 12233, Riyadh, Saudi Arabia.
  • Department of Pediatrics, College of Medicine, Taibah University, Al-Madinah, 41491, Saudi Arabia.
  • Department of Infection prevention and control, Prince Mohammad Bin Abdulaziz Hospital, National Guard Health Affairs, Al-Madinah, 41491, Saudi Arabia.
  • Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, 11671, Saudi Arabia.
  • College of Medicine and Health Science, Khalifa University, 127788, Abu Dhabi, United Arab Emirates.
  • Sheikh Khalifa Medical City, Abu Dhabi Health Services Company (SEHA), 51900, Abu Dhabi, United Arab Emirates.
  • Department of Microbiology, National Reference laboratory, Cleveland clinic Abu Dhabi, 92323, Abu Dhabi, United Arab Emirates.
  • Department of Pathology, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, 505055, Dubai, United Arab Emirates.
  • Department of Pathology and Laboratory Medicine, Security Forces Hospital Program, Riyadh, Saudi Arabia.
  • College of Medicine, Alfaisal University, 11533, Riyadh, Saudi Arabia.
  • Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, 31311, Dhahran, Saudi Arabia.
  • Department of Public Health and Nutrition, The University of Haripur, 22610, Haripur, Pakistan.
  • SR Sanjeevani Hospital, 56517, Kalyanpur, Siraha, Nepal.
  • Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, 411018, Pune, Maharashtra, India.
  • Department of Paediatrics, Hospital and Research Centre, Dr. D. Y. Patil Medical College, Dr. D. Y. Patil Vidyapeeth, 411018, Pune, Maharashtra, India.
  • School of Pharmaceutical Sciences, Lovely Professional University, City: Phagwara-144411, Country, India.
  • Center for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital, Saveetha University, Chennai, India.
  • Noida Institute of Engineering and Technology (Pharmacy Institute), Greater, Noida, India.
  • Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, 140417, India.
  • Chitkara Centre for Research and Development, Chitkara University, 174103, Himachal Pradesh, India.
  • Clinical Microbiology, RDC, Manav Rachna International Institute of Research and Studies, 121004, Faridabad, Haryana, India.
  • Dr Lal PathLabs - Nepal, 44600, Chandol-4, Maharajgunj, Kathmandu, Nepal.
  • Research and Enterprise, University of Cyberjaya, Persiaran Bestari, Cyber 11, 63000, Cyberjaya, Selangor, Malaysia.
  • IES Institute of Pharmacy, IES University, 462044, Bhopal, Madhya Pradesh, India.
  • New Delhi Institute of Management, Delhi, India.

Abstract

BACKGROUND

The COVID-19 pandemic has significantly impacted public health, with emerging evidence suggesting substantial effects on maternal and neonatal health. This systematic review and meta-analysis aimed to quantify the prevalence and risk of respiratory distress syndrome (RDS) in newborns born to mothers infected with SARS-CoV-2, the virus responsible for COVID-19.

METHODS

We conducted a literature search in Embase, PubMed, and Web of Science up to April 20, without language or date restrictions. Observational studies reporting on the prevalence or risk of RDS among newborns from mothers with confirmed SARS-CoV-2 infection were included. Quality assessment was performed using the JBI tool. Statistical analysis was performed by using R software version 4.3.

RESULTS

Twenty-two studies met the inclusion criteria. The pooled prevalence of RDS among newborns born to COVID-19-infected mothers was 11.5% (95% CI: 7.4-17.3%), with significant heterogeneity (I² = 93%). Newborns from infected mothers had a significantly higher risk of developing RDS, with a pooled risk ratio (RR) of 2.69 (95% CI: 1.77 to 4.17).

CONCLUSION

Newborns born to mothers with COVID-19 have a substantially increased risk of developing RDS. These findings emphasize the need for vigilant monitoring and appropriate management of pregnant women with COVID-19 to mitigate adverse neonatal outcomes.

MeSH

Mothers, Infant, Newborn, Covid-19, Prevalence, Respiratory Distress Syndrome, Communicable Diseases, Infections

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