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Journal Article Epublish 3 citations

PubMed: 39568811 DOI: 10.3389/fendo.2024.1492741

Predictive analysis of osteoarthritis and chronic pancreatitis comorbidity: complications and risk factors.

Front Endocrinol (Lausanne) 15:1492741

Authors: Iryna Halabitska, Pavlo Petakh, Valentyn Oksenych, Oleksandr Kamyshnyi

Affiliations

  • Department of Therapy and Family Medicine, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
  • Department of Biochemistry and Pharmacology, Uzhhorod National University, Uzhhorod, Ukraine.
  • Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
  • Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

Abstract

Background

The comorbidity of chronic pancreatitis (CP) in patients with osteoarthritis (OA) is insufficiently studied, and the reciprocal impact of these conditions remains poorly understood. This study aimed to investigate potential predictors for the development of CP in OA patients, as well as associated complications.

Methods

A cohort of 181 patients was categorized into four groups: a control group (n=30), patients with OA (n=68), patients with CP (n=31), and patients with OA and comorbid CP (n=52). All four groups had no statistical differences in age and gender. The study utilized the WOMAC index, Visual Analog Scale (VAS), Lequesne index, biochemical assays, and advanced statistical methods to assess joint status in OA patients with comorbid CP. It explored potential predictors of comorbidity development and associated complications.

Results

The study revealed that concurrent CP in OA exacerbates progression and contributes to malnutrition. Body Mass Index (BMI) emerged as a potential predictor for CP comorbidity development in OA patients. Factors such as the WOMAC total score, fecal elastase-1, C-reactive protein (CRP), ferritin, retinol, tocopherol, 25-hydroxyvitamin D3, and BMI were found to influence the development of comorbidity of CP in OA. Additionally, Gastrointestinal Symptom Rating Scale-Diarrhea Syndrome (GSRS-DS), Gastrointestinal Symptom Rating Scale-Constipation Syndrome (GSRS-CS), Qualitative Assessment of the Symptoms and Impact of Pancreatic Exocrine Insufficiency Domain A (PEI-Q-A), retinol, tocopherol, and iron were identified as potential predictors comorbidity CP with exocrine pancreatic insufficiency in OA patients.

Conclusion

The presence of CP in OA patients exacerbates disease progression and complications, necessitating further investigation.

MeSH

Comorbidity, Exocrine Pancreatic Insufficiency, Pancreatitis, Chronic, Osteoarthritis, Cohort Studies, Tocopherols, Aged, Pancreatitis, Risk Factors

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