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Publications

Journal Article Review Epublish 2 citations

PubMed: 39578455 DOI: 10.1038/s41514-024-00181-1

Emerging insights in senescence: pathways from preclinical models to therapeutic innovations.

NPJ Aging 10(1):53

Authors: Luke Mansfield, Valentina Ramponi, Kavya Gupta, Thomas Stevenson, Abraham Binoy Mathew, Agian Jeffilano Barinda, Florencia Herbstein, Samir Morsli

Affiliations

  • The Bateson Centre, School of Medicine and Population Health, The University of Sheffield, Western Bank, Sheffield, UK.
  • Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
  • Department of Cellular and Molecular Biology and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
  • Department of Biomedicine, University of Bergen, Bergen, Norway.
  • Department of Developmental Biology and Genetics, Biological Sciences, Indian Institute of Science, Bangalore, India.
  • Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
  • Metabolic, Cardiovascular, and Aging Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
  • Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society, Buenos Aires, Argentina.
  • Karolinska Institutet, Department of Cell and Molecular Biology, Biomedicum Q6A, Stockholm, Sweden.

Abstract

Senescence is a crucial hallmark of ageing and a significant contributor to the pathology of age-related disorders. As committee members of the young International Cell Senescence Association (yICSA), we aim to synthesise recent advancements in the identification, characterisation, and therapeutic targeting of senescence for clinical translation. We explore novel molecular techniques that have enhanced our understanding of senescent cell heterogeneity and their roles in tissue regeneration and pathology. Additionally, we delve into in vivo models of senescence, both non-mammalian and mammalian, to highlight tools available for advancing the contextual understanding of in vivo senescence. Furthermore, we discuss innovative diagnostic tools and senotherapeutic approaches, emphasising their potential for clinical application. Future directions of senescence research are explored, underscoring the need for precise, context-specific senescence classification and the integration of advanced technologies such as machine learning, long-read sequencing, and multifunctional senoprobes and senolytics. The dual role of senescence in promoting tissue homoeostasis and contributing to chronic diseases highlights the complexity of targeting these cells for improved clinical outcomes.

MeSH

Cells, Pathology, Therapeutics, Tissues

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