Journal Article Epublish
PubMed: 39591107 DOI: 10.3390/vaccines12111204
Re-Evaluation and Retrospective Comparison of Serum Neutralization Induced by Three Different Types of Inactivated SARS-CoV-2 Vaccines.
Vaccines (Basel) 12(11)
Authors: Weiyu Jiang, Jianbo Wu, Jiaying He, Anqi Xia, Wei Wu, Yidan Gao, Qianqian Zhang, Xiaofang Peng, Qiaochu Jiang, Song Xue, Qiao Wang
Affiliations
- Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
- Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
- Microbiological Testing Department, Baoshan District Center for Disease Control and Prevention, Shanghai 201901, China.
- Department of Clinical Laboratory, Shandong Cancer Hospital and Institute, Jinan 250117, China.
- Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Abstract
BACKGROUND
During the COVID-19 pandemic, three different types of inactivated SARS-CoV-2 vaccines, namely BBIBP-CorV, WIBP-CorV and CoronaVac, were manufactured and used for vaccination in China. However, as far as we know, no comparison of their induced serum neutralization has been carried out so far, possibly due to the regional difference in vaccine distribution, the difficulty in undertaking a comprehensive evaluation, and the intention to avoid unnecessary bias in populations for a certain type of inactivated vaccine.
METHODS
Since all three of these inactivated vaccines are no longer produced and used for vaccination, here, we retrospectively compared the serum neutralizing activities induced by these three different types of inactivated SARS-CoV-2 vaccines.
RESULTS
Compared with unvaccinated uninfected control donors, primary inactivated vaccination (232 donors) induced increased serum neutralizing titers against wildtype SARS-CoV-2 in around 70% of donors during the first 100 days. However, the neutralization effect waned quickly after 100 days, and significantly diminished against Delta and Omicron (B.1.1.529) variants. Moreover, the newly emerged Omicron variants, such as BA.2.75, BA.4/5, BF.7, BQ.1.1, and XBB, almost fully evaded the induced serum neutralization activity.
CONCLUSIONS
These three distinct types of inactivated vaccines, namely BBIBP-CorV, WIBP-CorV, and CoronaVac, induced serum neutralization in most vaccinated populations but in a short-term and variant-evaded manner with no significant difference among these inactivated vaccines.
MeSH
Sars-Cov-2, Serum, Vaccines, Covid-19 Vaccines, Vaccines, Inactivated, Vaccination, Severe Acute Respiratory Syndrome-Related Coronavirus