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Publications

Journal Article Review Ppublish 4 citations

PubMed: 39592529 DOI: 10.1007/s11154-024-09929-2

The development of growth hormone-releasing hormone analogs: Therapeutic advances in cancer, regenerative medicine, and metabolic disorders.

Rev Endocr Metab Disord 26(3):385-396

Authors: Andrew V Schally, Renzhi Cai, Xianyang Zhang, Wei Sha, Medhi Wangpaichitr

Affiliations

  • Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA. Miami VA Healthcare System, Endocrine and Polypeptide Institute, Miami, FL, USA. Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA. Department of Pathology, University of Miami Miller School of Medicine, Miami, FL, USA. Sylvester Comprehensive Cancer Center, Miami, FL, USA. South FL VA Foundation for Research and Education, Miami, FL, USA.
  • Miami VA Healthcare System, Endocrine and Polypeptide Institute, Miami, FL, USA. Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Miami VA Healthcare System, Endocrine and Polypeptide Institute, Miami, FL, USA.
  • Department of Pathology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Miami VA Healthcare System, Endocrine and Polypeptide Institute, Miami, FL, USA.
  • Sylvester Comprehensive Cancer Center, Miami, FL, USA.
  • Department of Surgery, Division of Thoracic Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  • South FL VA Foundation for Research and Education, Miami, FL, USA.

Abstract

Growth Hormone-Releasing Hormone (GHRH) and its analogs have gained significant attention for their therapeutic potential across various domains, including oncology, regenerative medicine, and metabolic disorders. Originally recognized for its role in regulating growth hormone (GH) secretion, GHRH has since been discovered to exert broader physiological effects beyond the pituitary gland, with GHRH receptors identified in multiple extrahypothalamic tissues, including tumor cells. This review explores the development of both GHRH agonists and antagonists, focusing on their mechanisms of action, therapeutic applications, and future potential. GHRH agonists have shown promise in promoting tissue regeneration, improving cardiac function, and enhancing islet survival in diabetes. Meanwhile, GHRH antagonists, particularly those in the MIA and AVR series, demonstrate potent antitumor activity by inhibiting cancer cell proliferation and downregulating growth factor pathways, while also exhibiting anti-inflammatory properties. Preclinical studies in models of lung, prostate, breast, and gastrointestinal cancers indicate that GHRH analogs could offer a novel therapeutic approach with minimal toxicity. Additionally, GHRH antagonists are being investigated for their potential in treating neurodegenerative diseases and inflammatory conditions. This review highlights the versatility of GHRH analogs as a promising class of therapeutic agents, poised to impact multiple fields of medicine.

MeSH

Cells, Growth Hormone-Releasing Hormone, Growth, Regenerative Medicine, Neoplasms, Hormones, Therapeutics, Tissues, Growth Hormone, Endocrine System Diseases

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