Journal Article Review Epublish 2 citations
PubMed: 39595034 DOI: 10.3390/biomedicines12112468
TGF-β Signaling in Microglia: A Key Regulator of Development, Homeostasis and Reactivity.
Biomedicines 12(11)
Authors: Lulin Li, Bryan Sun, Odette A Harris, Jian Luo
Affiliations
- Palo Alto Veterans Institute for Research, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.
- Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
- Polytrauma System of Care, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.
Abstract
Microglia, the resident immune cells of the central nervous system (CNS), are crucial for normal brain development and function. They become reactive in response to brain injury and disease, a process known as microglial reactivity. This reactivity, along with microglial homeostasis, is tightly regulated by the local microenvironment and interactions with surrounding cells. The TGF-β signaling pathway plays an essential role in this regulation. Recent genetic studies employing microglia-specific manipulation of the TGF-β signaling pathway have shed light on its significance in microglial development, homeostasis and reactivity. This review provides an updated overview of how TGF-β signaling modulates microglial function and reactivity, contributing to our understanding of microglial biology in health and disease.
MeSH
Microglia, Cells, Homeostasis, Brain
Cited by
- Microbial genetic composition regulates host social behavior. Gut Microbes, 2025
- Blood-brain barrier disruption: a pervasive driver and mechanistic link between traumatic brain injury and Alzheimer's disease. Transl Neurodegener, 2025
- Developmental Stage-Dependent Transcriptomic Responses to Neonatal Intraventricular Hemorrhage. bioRxiv, 2025
- Bidirectional Interplay Between Microglia and Mast Cells. Int J Mol Sci, 2025