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Journal Article Review Epublish 2 citations

PubMed: 39595208 DOI: 10.3390/biomedicines12112645

Advancements in Autophagy Modulation for the Management of Oral Disease: A Focus on Drug Targets and Therapeutics.

Biomedicines 12(11)

Authors: Md Ataur Rahman, Mushfiq Hassan Shaikh, Rajat Das Gupta, Nazeeba Siddika, Muhammad Saad Shaikh, Muhammad Sohail Zafar, Bonglee Kim, Ehsanul Hoque Apu

Affiliations

  • Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
  • Department of Otolaryngology-Head and Neck Surgery, Western University, London, ON N6A 4V2, Canada.
  • School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
  • Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
  • Oral Health Sciences Division, College of Dental Medicine, Lincoln Memorial University, Knoxville, TN 37923, USA.
  • Department of Oral Biology, Sindh Institute of Oral Health Sciences, Jinnah Sindh Medical University, Karachi 75510, Pakistan.
  • Department of Clinical Sciences, College of Dentistry, Ajman University, Ajman P.O. Box 346, United Arab Emirates. Centre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman P.O. Box 346, United Arab Emirates. School of Dentistry, Jordan University, Amman 19328, Jordan. Department of Dental Materials, Islamic International Dental College, Riphah International University, Islamabad 44000, Pakistan.
  • Department of Pathology, College of Korean Medicine, Kyung Hee University, 1-5 Hoegidong Dongdaemun-gu, Seoul 02447, Republic of Korea. Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
  • Department of Biomedical Sciences, College of Dental Medicine, Lincoln Memorial University, Knoxville, TN 37923, USA.
  • Centre for International Public Health and Environmental Research, Bangladesh (CIPHER,B), Dhaka 1207, Bangladesh.
  • Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48105, USA.

Abstract

Autophagy is an intrinsic breakdown system that recycles organelles and macromolecules, which influences metabolic pathways, differentiation, and thereby cell survival. Oral health is an essential component of integrated well-being, and it is critical for developing therapeutic interventions to understand the molecular mechanisms underlying the maintenance of oral homeostasis. However, because of the complex dynamic relationship between autophagy and oral health, associated treatment modalities have not yet been well elucidated. Determining how autophagy affects oral health at the molecular level may enhance the understanding of prevention and treatment of targeted oral diseases. At the molecular level, hard and soft oral tissues develop because of complex interactions between epithelial and mesenchymal cells. Aging contributes to the progression of various oral disorders including periodontitis, oral cancer, and periapical lesions during aging. Autophagy levels decrease with age, thus indicating a possible association between autophagy and oral disorders with aging. In this review, we critically review various aspects of autophagy and their significance in the context of various oral diseases including oral cancer, periapical lesions, periodontal conditions, and candidiasis. A better understanding of autophagy and its underlying mechanisms can guide us to develop new preventative and therapeutic strategies for the management of oral diseases.

MeSH

Cells, Oral Health, Autophagy, Molecular Biology, Pharmaceutical Preparations, Aging, Neoplasms, Therapeutics, Periodontitis, Mouth Neoplasms, Wounds And Injuries

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