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Publications

Journal Article Review Epublish 2 citations

PubMed: 39596741 DOI: 10.3390/antibiotics13111047

Nanoparticle-Based Nitric Oxide Donors: Exploring Their Antimicrobial and Anti-Biofilm Capabilities.

Antibiotics (Basel) 13(11)

Authors: Gonzalo Tortella Fuentes, Paola Fincheira, Olga Rubilar, Sebastian Leiva, Ivette Fernandez, Mauricio Schoebitz, Milena T Pelegrino, André Paganotti, Roberta Albino Dos Reis, Amedea B Seabra

Affiliations

  • Centro de Excelencia en InvestigaciĂ³n BiotecnolĂ³gica Aplicada al Medio Ambiente-CIBAMA, Facultad de IngenierĂ­a y Ciencias, Universidad de La Frontera, Temuco 4811230, Chile.
  • Departamento de IngenierĂ­a QuĂ­mica, Facultad de IngenierĂ­a y Ciencias, Universidad de La Frontera, Temuco 4811230, Chile.
  • Centro de Excelencia en InvestigaciĂ³n BiotecnolĂ³gica Aplicada al Medio Ambiente-CIBAMA, Facultad de IngenierĂ­a y Ciencias, Universidad de La Frontera, Temuco 4811230, Chile. Programa de Doctorado en Ciencias de Recursos Naturales, Universidad de La Frontera, Temuco 4811230, Chile.
  • Departamento de Suelos y Recursos Naturales, Facultad de AgronomĂ­a, Campus ConcepciĂ³n, Universidad de ConcepciĂ³n, Casilla 160-C, ConcepciĂ³n 4030000, Chile.
  • Center of Biotechnology, Universidad de ConcepciĂ³n, Barrio Universitario s/n, ConcepciĂ³n 4030000, Chile.
  • MirScience Therapeutics, SĂ£o Paulo 04020-040, SP, Brazil.
  • Departamento de FarmĂ¡cia, Universidade Federal de SĂ£o Paulo, Diadema 09972-270, SP, Brazil.
  • Centro de CiĂªncias Naturais e Humanas, Universidade Federal do ABC, Santo AndrĂ© 09606-045, SP, Brazil.

Abstract

Nitric oxide (NO) is an antimicrobial and anti-biofilm agent with significant potential for combating biofilm-associated infections and antibiotic resistance. However, owing to its high reactivity due to the possession of a free radical and short half-life (1-5 s), the practical application of NO in clinical settings is challenging. : This review explores the development of NO-releasing nanoparticles that provide a controlled, targeted delivery system for NO, enhancing its antimicrobial efficacy while minimizing toxicity. The review discusses various NO donors, nanoparticle platforms, and how NO disrupts biofilm formation and eradicates pathogens. Additionally, we examine the highly encouraging and inspiring results of NO-releasing nanoparticles against multidrug-resistant strains and their applications in medical and environmental contexts. This review highlights the promising role of NO-based nanotechnologies in overcoming the challenges posed by increasing antibiotic resistance and biofilm-associated infections. Although NO donors and nanoparticle delivery systems show great potential for antimicrobial and anti-biofilm uses, addressing challenges related to controlled release, toxicity, biofilm penetration, resistance, and clinical application is crucial.

MeSH

Nitric Oxide Donors, Nanoparticles, Biofilms, Infections