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Publications

Journal Article Epublish

PubMed: 39596777 DOI: 10.3390/antibiotics13111084

Diversity, Distribution, and Resistance Profiles of Bacterial Bloodstream Infections in Three Tertiary Referral Hospitals in Rwanda Between 2020 and 2022.

Antibiotics (Basel) 13(11)

Authors: Misbah Gashegu, Vedaste Ndahindwa, Edson Rwagasore, Albert Tuyishime, Clarisse Musanabaganwa, Noel Gahamanyi, Isabelle Mukagatare, Djibril Mbarushimana, Christopher Aird Green, Tafadzwa Dzinamarira, Ayman Ahmed, Claude Mambo Muvunyi

Affiliations

  • Rwanda Biomedical Center, Kigali P.O. Box 7162, Rwanda.
  • School of Public health, College of Medicine and Health Sciences, University of Rwanda, Kigali 3286, Rwanda.
  • University Teaching Hospital of Butare, Butare 15232, Rwanda.
  • School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • School of Health Systems & Public Health, University of Pretoria, Pretoria 0002, South Africa.
  • Institute of Endemic Diseases, University of Khartoum, Khartoum 11111, Sudan.

Abstract

: The burden of bacterial bloodstream infections (BSIs) is rapidly increasing in Africa including Rwanda. : This is a retrospective study that investigates the diversity, distribution, and antimicrobial susceptibility profiles of BSI bacteria in three tertiary referral hospitals in Rwanda between 2020 and 2022. : A total of 1532 blood culture tests were performed for visiting patients. Overall, the proportions of Gram-negative and Gram-positive bacteria were 48.2% and 51.8, respectively. was the predominant species accounting for 25% of all Gram-positive BSI species, and Klebsiella species represented 41% of all Gram-negative BSI species. Antimicrobial susceptibility testing revealed that Amikacin exhibited the highest activity against spp., spp., and in >92% of cases and spp. in 75.7%. Meropenem and Imipenem were highly efficacious to spp. (100% susceptibility), spp. (96.2% and 91.7%, respectively), and (94.7% and 95.5%, respectively). The susceptibility of spp., , and spp. to Vancomycin was 100%, 99.5%, and 97.1%, respectively. spp. was highly sensitive to Colistin (98.7%), Polymyxin B (85.6%), Imipenem (84.9%), and Meropenem (78.5%). : We recommend strengthening the implementation of integrated transdisciplinary and multisectoral One Health including AMR stewardship for the surveillance, prevention, and control of AMR in Rwanda.

MeSH

Tertiary Care Centers, Blood, Sepsis, Blood Culture, Bacteria, Infections

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