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Journal Article Epublish 1 citation

PubMed: 39597044 DOI: 10.3390/medicina60111859

Factors Influencing the Development and Severity of Cognitive Decline in Patients with Chronic Heart Failure.

Medicina (Kaunas) 60(11)

Authors: Marius Militaru, Daniel Florin Lighezan, Cristina Tudoran, Mariana Tudoran, Anda Gabriela Militaru

Affiliations

  • Department VIII, Neuroscience, Discipline of Neurology II, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.
  • Municipal Emergency Hospital Timisoara, Gheorghe Dima Street Nr. 5, 300254 Timisoara, Romania.
  • Center of Advanced Research in Cardiology and Hemostasology, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.
  • Department V, Internal Medicine I, Discipline of Medical Semiology I, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.
  • Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.
  • Center of Molecular Research in Nephrology and Vascular Disease, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.
  • County Emergency Hospital "Pius Brinzeu", L. Rebreanu Street, Nr. 156, 300723 Timisoara, Romania.

Abstract

: Considering the increasing prevalence of chronic heart failure (CHF) and cognitive decline (CD) observed in recent decades and the complex interrelation between these two pathologies often encountered in the same patient, in this study, we aimed to highlight the connection between CHF, defined as recommended by the European Society of Cardiology guidelines, and CD, evaluated by employing five neuropsychological scales. : Our study was conducted on 190 patients with very high cardiovascular risk profiles admitted between 5 September 2021 and 15 November 2023 in the Municipal Emergency Hospital Timisoara. Of these, 103 had CHF (group A) and 87 did not (group B). : Although similar concerning age, sex distribution, and risk factors (excepting lipid profile), patients from group A had lower Mini Mental State Evaluation (MMSE) and Montreal Cognitive Assessment (MoCA levels ( = 0.003, respectively, = 0.017) scores, more reduced daily activity ( = 0.021), and more severe depression ( = 0.015) compared to group B. We documented statistically significant correlations between left-ventricular ejection fraction (LVEF) and the levels of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), as well as with the results of MMSE (r = 0.226, = 0.002 and r = -0.275, = 0.005, respectively), daily activity, and depression ( ˂ 0.001). Multi-logistic regression models indicated age, blood pressure values, decreased daily activity, and depression as risk factors for CD in patients with CHF. : In patients with CHF, there is an increased propensity of CD, with a direct relationship between MMSE and LVEF levels and an indirect one between MMSE and NT-pro-BNP levels. The concomitance of depression and reduced activity levels are aggravating CD in these patients.

MeSH

Depression, Dementia, Heart Failure, Heart, Cognitive Dysfunction, Risk Factors

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