Journal Article Review Epublish 1 citation
PubMed: 39598790 DOI: 10.3390/molecules29225403
Insights into SARS-CoV-2: Small-Molecule Hybrids for COVID-19 Treatment.
Molecules 29(22)
Authors: Maria Luisa Navacchia, Caterina Cinti, Elena Marchesi, Daniela Perrone
Affiliations
- Institute for Organic Synthesis and Photoreactivity (ISOF), National Research Council of Italy (CNR), 40129 Bologna, Italy.
- Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.
- Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy.
Abstract
The advantages of a treatment modality that combines two or more therapeutic agents with different mechanisms of action encourage the study of hybrid functional compounds for pharmacological applications. Molecular hybridization, resulting from a covalent combination of two or more pharmacophore units, has emerged as a promising approach to overcome several issues and has also been explored for the design of new drugs for COVID-19 treatment. In this review, we presented an overview of small-molecule hybrids from both natural products and synthetic sources reported in the literature to date with potential antiviral -SARS-CoV-2 activity.
MeSH
Sars-Cov-2, Drug Design, Covid-19, Therapeutics, Severe Acute Respiratory Syndrome-Related Coronavirus, Small Molecules