Abstract

Psoriasis and psoriatic arthritis (PsA) are chronic autoimmune diseases characterized by persistent inflammation and oxidative imbalance. Oxidative stress, caused by excessive production of reactive oxygen species (ROS) and dysfunction in antioxidant mechanisms, plays a critical role in the pathogenesis of both conditions, leading to increased inflammatory processes and tissue damage. This study aims to review current antioxidant-based therapeutic options and analyze oxidative stress biomarkers in the context of psoriasis and PsA. Based on available literature, key biomarkers, such as malondialdehyde (MDA), advanced glycation end-products (AGEs), and advanced oxidation protein products (AOPP), were identified as being elevated in patients with psoriasis and PsA. Conversely, antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), showed reduced activity, correlating with symptom severity. The study also examines the efficacy of various antioxidant therapies, including curcumin, resveratrol, coenzyme Q10, and vitamins C and E, which may aid in reducing oxidative stress and alleviating inflammation. The findings indicated that antioxidants can play a significant role in alleviating symptoms and slowing the progression of psoriasis and PsA through modulation of redox mechanisms and reduction of ROS levels. Antioxidant-based therapies offer a promising direction in treating autoimmune diseases, highlighting the need for further research on their efficacy and potential clinical application.

MeSH

Arthritis, Psoriatic, Stress, Physiological, Arthritis, Oxidative Stress, Biomarkers, Antioxidants, Advanced Oxidation Protein Products, Curcumin, Autoimmune Diseases, Therapeutics, Psoriasis

Cited by

• Oxidative Stress and Skin Diseases: The Role of Lipid Peroxidation. Antioxidants (Basel), 2025
• The Therapeutic Potential of Galium verum for Psoriasis: A Combined Phytochemical, In Silico, and Experimental Approach. Int J Mol Sci, 2025
• Recent advancement of fisetin-based nanoformulations in the management of psoriasis. Discov Nano, 2025
• The Role of NADPH Oxidase 2 in Leukocytes. Antioxidants (Basel), 2025
• The Role of Diet in Modulating Inflammation and Oxidative Stress in Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis. Nutrients, 2025
• The Role of Oxidative Stress in Skin Disorders Associated with Alcohol Dependency and Antioxidant Therapies. Molecules, 2025
• Oxidative Stress in Psoriasis Vulgaris Patients: Analysis of Asymmetric Dimethylarginine, Malondialdehyde, and Glutathione Levels. Medicina (Kaunas), 2025
• Cardiometabolic Risk in Psoriatic Arthritis: A Hidden Burden of Inflammation and Metabolic Dysregulation. Metabolites, 2025