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Publications

Journal Article Epublish

PubMed: 39604464 DOI: 10.1038/s41598-024-80985-z

Causal relationship between lipidome and acute respiratory distress syndrome.

Sci Rep 14(1):29523

Authors: Ruoyi Shen, Zhijiang Qi, Xu Huang, Jingen Xia, Qingyuan Zhan

Affiliations

  • Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China. Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Beijing, People's Republic of China. National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Disease, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
  • Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Beijing, People's Republic of China.
  • Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Beijing, People's Republic of China. National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Disease, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
  • Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China. Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Beijing, People's Republic of China. National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Disease, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
  • Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China. Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Beijing, People's Republic of China. National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Disease, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Abstract

Acute respiratory distress syndrome (ARDS), with high morbidity and mortality, is a common clinical syndrome of acute respiratory failure caused by diffuse lung inflammation and edema. ARDS can precipitate in various ways. The complex pathophysiology of ARDS involves the activation and dysregulation of multiple metabolisms and immune responses. Using summary-level data from a genome-wide association study (GWAS), a two-sample Mendelian randomization (MR) analysis of 179 genetically predicted lipid species and ARDS (375 cases, 406,518 controls) was performed and validated in plasma and pulmonary edema fluid from 24 patients. Furthermore, we used a two-step MR to quantify the effect of immune cell-mediated lipids on ARDS. We identified 8 lipids (Cholesterol, Phosphatidylcholine (14:0_16:0), Phosphatidylcholine (16:0_20:5), Phosphatidylcholine (18:0_18:2), Phosphatidylethanolamine (18:1_18:1), Triacylglycerol (51:2), Triacylglycerol (52:4), and Triacylglycerol (54:3) ) associated with ARDS. The proportions of genetically-predicted lipids mediated by the four types of immune cells were determined. Sensitivity analysis did not reveal any obvious pleiotropy or heterogeneity. Our study demonstrates the power of multivariate genetic analysis in correlated lipidomic data and reveals genetic links between ARDS and lipid species beyond standard lipids.

MeSH

Cells, Natural Science Disciplines, Respiratory Distress Syndrome, Edema