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Journal Article Review Epublish 14 citations

PubMed: 39614268 DOI: 10.1186/s12943-024-02172-y

Mechanisms and cross-talk of regulated cell death and their epigenetic modifications in tumor progression.

Mol Cancer 23(1):267

Authors: Ruimin He, Yifan Liu, Weijie Fu, Xuan He, Shuang Liu, Desheng Xiao, Yongguang Tao

Affiliations

  • Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China. Cancer Research Institute and School of Basic Medicine, Central South University, Changsha, Hunan, 410078, China. Department of Pathology, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital, Central South University, Hunan, 410078, China.
  • Department of Oncology, Institute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China. Cancer Research Institute and School of Basic Medicine, Central South University, Changsha, Hunan, 410078, China. Department of Pathology, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital, Central South University, Hunan, 410078, China. Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. Department of Thoracic Surgery, Hunan Key Laboratory of Early Diagnosis and Precision Therapy in Lung Cancer, Second Xiangya Hospital, Central South University, Changsha, 410011, China. Furong Laboratory, Xiangya School of Medicine, Central South University, Hunan, 410078, China.

Abstract

Cell death is a fundamental part of life for metazoans. To maintain the balance between cell proliferation and metabolism of human bodies, a certain number of cells need to be removed regularly. Hence, the mechanisms of cell death have been preserved during the evolution of multicellular organisms. Tumorigenesis is closely related with exceptional inhibition of cell death. Mutations or defects in cell death-related genes block the elimination of abnormal cells and enhance the resistance of malignant cells to chemotherapy. Therefore, the investigation of cell death mechanisms enables the development of drugs that directly induce tumor cell death. In the guidelines updated by the Cell Death Nomenclature Committee (NCCD) in 2018, cell death was classified into 12 types according to morphological, biochemical and functional classification, including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, PARP-1 parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence and mitotic catastrophe. The mechanistic relationships between epigenetic controls and cell death in cancer progression were previously unclear. In this review, we will summarize the mechanisms of cell death pathways and corresponding epigenetic regulations. Also, we will explore the extensive interactions between these pathways and discuss the mechanisms of cell death in epigenetics which bring benefits to tumor therapy.

MeSH

Cells, Genes, Regulated Cell Death, Neoplasms, Immunogenic Cell Death, Autophagic Cell Death, Therapeutics, Apoptosis, Cell Death

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