System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Review Ppublish 2 citations

PubMed: 39614898 DOI: 10.1007/s00210-024-03672-w

Therapeutic role of naringin in cancer: molecular pathways, synergy with other agents, and nanocarrier innovations.

Naunyn Schmiedebergs Arch Pharmacol 398(4):3595-3615

Authors: Abdulsalam Alhalmi, Saima Amin, Tanya Ralli, Khaled Saeed Ali, Kanchan Kohli

Affiliations

  • Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.
  • Department of Pharmaceutics, Faculty of Pharmacy, University of Aden, Aden, Yemen.
  • School of Pharmacy, COER University, Roorkee, 247667, India.
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Aden, Aden, Yemen.
  • Faculty of Pharmacy, Lloyd Institute of Management and Technology, Greater Noida, 201308, India.
  • Department of Pharmaceutical Sciences, Gurugram University, Haryana, 122003, India.

Abstract

Naringin, a flavanone glycoside found abundantly in citrus fruits, is well-known for its various pharmacological properties, particularly its significant anticancer effects. Research, both in vitro and in vivo, has shown that naringin is effective against several types of cancer, including liver, breast, thyroid, prostate, colon, bladder, cervical, lung, ovarian, brain, melanoma, and leukemia. Its anticancer properties are mediated through multiple mechanisms, such as apoptosis induction, inhibition of cell proliferation, cell cycle arrest, and suppression of angiogenesis, metastasis, and invasion, all while exhibiting minimal toxicity and adverse effects. Naringin's molecular mechanisms involve the modulation of essential signaling pathways, including PI3K/Akt/mTOR, FAK/MMPs, FAK/bads, FAKp-Try397, IKKs/IB/NF-κB, JNK, ERK, β-catenin, p21CIPI/WAFI, and p38-MAPK. Additionally, it targets several signaling proteins, such as Bax, TNF-α, Zeb1, Bcl-2, caspases, VEGF, COX-2, VCAM-1, and interleukins, contributing to its wide-ranging antitumor effects. The remarkable therapeutic potential of naringin, along with its favorable safety profile, highlights its promise as a candidate for cancer treatment. This comprehensive review examines the molecular mechanisms behind naringin's chemopreventive and anticancer effects, including its pharmacokinetics and bioavailability. Furthermore, it discusses advancements in nanocarrier technologies designed to enhance these characteristics and explores the synergistic benefits of combining naringin with other anticancer agents, focusing on improved therapeutic efficacy and drug bioavailability.

MeSH

Cells, Cell Proliferation, Biological Availability, Neoplasms, Pharmacology, Therapeutics

Cited by