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Publications

Case Reports Journal Article Epublish

PubMed: 39630750 DOI: 10.31744/einstein_journal/2024RC1105

Coexistent sickle cell anemia and autoimmune hemolytic anemia in two adolescents.

Einstein (Sao Paulo) 22:eRC1105

Authors: Vinícius Reis Soares, Bruna Paccola Blanco, Carla Luana Dinardo, Marlene Pereira Garanito

Affiliations

  • Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
  • Fundação Pró-Sangue, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Abstract

The development of alloantibodies or autoantibodies is a complication observed in sickle cell disease. Autoimmunization occurs in 7.6-12% of chronically or intermittently transfused patients with sickle cell disease; however, the clinical implications of autoAbs are unclear. Few studies have focused on pediatric sickle cell disease and autoimmune hemolytic anemia. Herein, we present the coexistence of sickle cell disease and autoimmune hemolytic anemia in two adolescent patients, focusing on their pathophysiology, diagnosis, clinical management, and outcomes.

MeSH

Cells, Anemia, Sickle Cell, Anemia, Anemia, Hemolytic, Adolescent, Anemia, Hemolytic, Autoimmune