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Publications

Journal Article Epublish

PubMed: 39664557 DOI: 10.3389/fpubh.2024.1488558

Associations between ethylene oxide exposure and biological age acceleration: evidence from NHANES 2013-2016.

Front Public Health 12:1488558

Authors: Xinyun Chen, Fangyu Shi, Wenhui Yu, Chunying He, Shenju Gou, Ping Fu

Affiliations

  • Department of Health Management, Health Management Center, General Practice Center, West China Hospital, Sichuan University, Chengdu, China.
  • Department of Nephrology, Institute of Kidney Diseases, West China Hospital, Sichuan University, Chengdu, China.

Abstract

Introduction

Population aging is a global concern, with the World Health Organization predicting that by 2030, one in six individuals worldwide will be 60 years or older. Ethylene oxide (EO) is a widely used industrial chemical with potential health risks, including associations with age-related diseases. This study investigates the relationship between EO exposure and biological age acceleration.

Method

Data from the National Health and Nutrition Examination Survey (NHANES) 2013-2016 were analyzed, including 3,155 participants after exclusions. Blood EO levels were measured using hemoglobin adducts (HbEO). Biological age acceleration was assessed using two methods: Phenotypic Age Acceleration (PhenoAgeAccel) and Klemera-Doubal Method Age Acceleration (KDM-AA). Linear and logistic regression models were applied, adjusting for various covariates, and restricted cubic spline (RCS) regression was used to explore non-linear associations.

Results

Higher EO exposure was significantly associated with increased PhenoAgeAccel and KDM-AA across all models. In the continuous model, substantial positive associations were observed (PhenoAgeAccel:  = 0.73,  < 0.001; KDM-AA:  = 0.66,  < 0.001) in Model 3. Quintile analysis indicated a trend of increasing biological age acceleration with higher EO exposure. RCS regression demonstrated a significant linear relationship between EO exposure and PhenoAgeAccel ( for non-linearity = 0.067), as well as with KDM-AA ( for non-linearity = 0.083). Subgroup and interaction analyses revealed significant modifying effects by factors such as body mass index, gender, diabetes status, and physical activity level.

Conclusion

Our study demonstrates a significant association between EO exposure and accelerated biological aging. These findings highlight the need for further prospective and mechanistic studies to validate and explore this phenomenon.

MeSH

Aging, Public Health, Ethylene Oxide