Journal Article Review Ppublish 11 citations
PubMed: 39681336 DOI: 10.1146/annurev-publhealth-060222-015657
Quantification of Epigenetic Aging in Public Health.
Annu Rev Public Health 46(1):91-110
Authors: Cynthia D J Kusters, Steve Horvath
Affiliations
- Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA;.
- Altos Labs, Cambridge, United Kingdom;.
- Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, California, USA.
Abstract
Estimators of biological age hold promise for use in preventive medicine, for early detection of chronic conditions, and for monitoring the effectiveness of interventions aimed at improving population health. Among the promising biomarkers in this field are DNA methylation-based biomarkers, commonly referred to as epigenetic clocks. This review provides a survey of these clocks, with an emphasis on second-generation clocks that predict human morbidity and mortality. It explores the validity of epigenetic clocks when considering factors such as race, sex differences, lifestyle, and environmental influences. Furthermore, the review addresses the current challenges and limitations in this research area.
MeSH
Aging, Public Health, Biomarkers
Cited by
- Colonic Aging and Colorectal Cancer: An Unignorable Interplay and Its Translational Implications. Biology (Basel), 2025
- Community Threat, Positive Parenting, and Accelerated Epigenetic Aging: Longitudinal Links from Childhood to Adolescence. medRxiv, 2025
- Discrimination, Coping, and DNAm Accelerated Aging Among African American Mothers of the InterGEN Study. Epigenomes, 2025