Journal Article Review Research Support, Non-U.S. Gov't Epublish
PubMed: 39682744 DOI: 10.3390/cells13231996
Beta-Cell-Derived Extracellular Vesicles: Mediators of Intercellular Communication in the Islet Microenvironment in Type 1 Diabetes.
Cells 13(23)
Authors: Mette C Dekkers, Xudong Pu, Agustin Enciso-Martinez, Arnaud Zaldumbide
Affiliations
- Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
- Oncode Institute, 3521 AL Utrecht, The Netherlands.
- Amsterdam Vesicle Center, Biomedical Engineering and Physics and Laboratory of Experimental Clinical Chemistry, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Abstract
Type 1 diabetes (T1D) is a chronic autoimmune disorder characterised by an autoimmune response specifically mounted against the insulin-producing beta cells. Within the islet, high cellular connectivity and extensive vascularisation facilitate intra-islet communication and direct crosstalk with the surrounding tissues and the immune system. During the development of T1D, cytokines and extracellular vesicles released by beta cells can contribute to the recruitment of immune cells, further amplifying autoimmunity and aggravating beta cell damage and dysfunction. In this review, we will evaluate the role of beta-cell-derived extracellular vesicles as mediators of the autoimmune response and discuss their potential for early diagnosis and new therapeutic strategies in T1D.
MeSH
Diabetes Mellitus, Cells, Extracellular Vesicles, Communication, Diabetes Mellitus, Type 1