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Publications

Journal Article Epublish

PubMed: 39735257 DOI: 10.3389/fcimb.2024.1474998

Diagnostic and prognostic values of NSCLC patients with or without obstructive pneumonia after sleeve lobectomy.

Front Cell Infect Microbiol 14:1474998

Authors: Yuxia Huang, Lan Zhang, Wentian Zhang, Na Lv, Tao Wang

Affiliations

  • Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou, China. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
  • Department of Operating Room, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
  • Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Abstract

Objective

We aimed to identify the diagnostic value of next-generation sequencing (NGS) of bronchoalveolar lavage fluid (BALF) from patients with non-small-cell lung cancer (NSCLC).

Methods

Forty patients who were initially diagnosed with pulmonary nodules were enrolled. Frozen section histology was used to identify the NSCLC cell types. NGS of collected BALF samples was used for microbial identification. We compared the bacterial and viral distributions in BALF samples from patients with NSCLC with and without obstructive pneumonia as well as their NSCLC drainage times following surgery.

Results

Of the 29 patients with NSCLC, eight had obstructive pneumonia. , , and were the top three bacteria present in almost 50% of patients, both with and without obstructive pneumonia. The viral detection rate was higher in the BALF of patients with NSCLC who did not have obstructive pneumonia. However, in patients with NSCLC and drain times of >5 days, the human herpes virus type 7 detection rate was higher following surgery than it was in patients with NSCLC who had drain times of ≤5 days.

Conclusion

Viral imbalance in NSCLC is closely related to the occurrence of obstructive pneumonia and postoperative drainage time.

MeSH

Cells, Drainage, Carcinoma, Non-Small-Cell Lung, Bronchoalveolar Lavage Fluid, Cell Biology, Pneumonia, Bacteria