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Journal Article Review Research Support, Non-U.S. Gov't Epublish 1 citation

PubMed: 39744229 DOI: 10.7150/thno.97192

Optical coherence tomography (OCT) and OCT angiography: Technological development and applications in brain science.

Theranostics 15(1):122-140

Authors: Luyao Yang, Pengyu Chen, Xiaofei Wen, Qingliang Zhao

Affiliations

  • School of Pen-Tung Sah Institute of Micro-Nano Science and Technology, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Center for Molecular Imaging and Translational Medicine, Department of Vascular & Tumor Interventional Radiology, The First Affiliated Hospital of Xiamen University, School of Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.

Abstract

Brain diseases are a leading cause of disability and death worldwide. Early detection can lead to earlier intervention and better outcomes for patients. In recent years, optical coherence tomography (OCT) and OCT angiography (OCTA) imaging have been widely used in stroke, traumatic brain injury (TBI), and brain cancer due to their advantages of in vivo, unlabeled, and high-resolution 3D microvessel imaging at the capillary resolution level. This review summarizes recent advances and challenges in living brain imaging using OCT/OCTA, including technique modality, types of diseases, and theoretical approach. Although there may still be many limitations, with the development of lasers and the advances in artificial intelligence are expected to enable accurate detection of deep cerebral hemodynamics and guide intraoperative tumor resection in vivo in the future.

MeSH

Brain Neoplasms, Nanomedicine, Ischemic Stroke, Tomography, Brain, Neoplasms, Angiography, Tomography, Optical Coherence, Brain Injuries, Traumatic

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