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Publications

Journal Article Epublish

PubMed: 39752432 DOI: 10.1371/journal.pone.0313759

Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid obesity.

PLoS One 20(1):e0313759

Authors: Pau Soldevila-Matías, Joan Vicent Sánchez-Ortí, Patricia Correa-Ghisays, Vicent Balanzá-Martínez, Gabriel Selva-Vera, Roberto Sanchis-Sanchis, Néstor Iglesias-García, Manuel Monfort-Pañego, Pilar Tomás-Martínez, Víctor M Victor, Benedicto Crespo-Facorro, Constanza San Martin Valenzuela, José Antonio Climent-Sánchez, Rosana Corral-Márquez, Inmaculada Fuentes-Durá, Rafael Tabarés-Seisdedos

Affiliations

  • Faculty of Psychology, University of Valencia, Valencia, Spain.
  • INCLIVA-Health Research Institute, Valencia, Spain.
  • Department of Psychology, Faculty of Health Sciences, European University of Valencia, Valencia, Spain.
  • TMAP-Evaluation Unit in Personal Autonomy, Dependency and Serious Mental Disorders, University of Valencia, Valencia, Spain.
  • Center for Biomedical Research in Mental Health Network (CIBERSAM), Health Institute Carlos III, Madrid, Spain.
  • Faculty of Psychology, University of Valencia, Valencia, Spain. INCLIVA-Health Research Institute, Valencia, Spain. TMAP-Evaluation Unit in Personal Autonomy, Dependency and Serious Mental Disorders, University of Valencia, Valencia, Spain. Center for Biomedical Research in Mental Health Network (CIBERSAM), Health Institute Carlos III, Madrid, Spain.
  • Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Valencia, Spain.
  • VALSME (VALencia Salut Mental i Estigma) Research Group, University of Valencia, Valencia, Spain.
  • Department of Physical Education and Sports, University of Valencia, Valencia, Spain.
  • Department of Didactics of Physical, Artistic and Music Education, University of Valencia, Valencia, Spain.
  • Mental Health Unit of Xàtiva, Lluís Alcanys Hospital, Valencia, Spain.
  • Service of Endocrinology and Nutrition, University Hospital Dr. Peset, Valencia, Spain.
  • Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain.
  • Department of Physiology, University of Valencia, Valencia, Spain.
  • Department of Psychiatry, University Hospital Virgen Del Rocio, IBIS-CSIC, University of Sevilla, Seville, Spain.
  • INCLIVA-Health Research Institute, Valencia, Spain. TMAP-Evaluation Unit in Personal Autonomy, Dependency and Serious Mental Disorders, University of Valencia, Valencia, Spain. Center for Biomedical Research in Mental Health Network (CIBERSAM), Health Institute Carlos III, Madrid, Spain. Department of Physiotherapy, University of Valencia, Valencia, Spain.
  • Mental Health Unit of Sagunto, Valencia, Spain.

Abstract

INTRODUCTION

This study aimed to evaluate the predictive validity and discriminatory ability of clinical outcomes, inflammatory activity, oxidative and vascular damage, and metabolic mechanisms for detecting significant improve maximum heart rate after physical activity training in individuals with psychiatric disorders and obesity comorbid using a longitudinal design and transdiagnostic perspective.

METHODS

Patients with major depressive disorder, bipolar disorder and, schizophrenia and with comorbid obesity (n = 29) were assigned to a 12-week structured physical exercise program. Peripheral blood biomarkers of inflammation, oxidative stress, vascular mechanisms, and metabolic activity, as well as neurocognitive and functional performance were assessed twice, before and after intervention. Maximum heart rate was considered a marker of effectiveness of physical activity. Mixed one-way analysis of variance and linear regression analyses were performed.

RESULTS

Individuals with psychiatric disorders and comorbid obesity exhibited an improvement in cognition, mood symptoms and body mass index, increase anti-inflammatory activity together with enhancement of the oxidative and cardiovascular mechanisms after physical activity training (p<0.05 to 0.0001; d = 0.47 to 1.63). A better clinical outcomes along with regulation of inflammatory, oxidative, and cardiovascular mechanisms were critical for predicting significant maximum heart rate variation over time (χ2 = 32.2 to 39.0, p < 0.0001).

CONCLUSIONS

The regulation of the anti-inflammatory mechanisms may be essential for maintained of healthy physical activity across psychiatric disorders and obesity. Likewise, inflammatory activity, oxidative stress, vascular and cardio-metabolic mechanisms may be a useful to identify individuals at greater risk of multi-comorbidity.

MeSH

Exercise, Bipolar Disorder, Heart Rate, Heart, Mental Disorders, Stress, Physiological, Oxidative Stress, Obesity