Journal Article Review Epublish 8 citations
PubMed: 39753605 DOI: 10.1038/s41526-024-00457-6
Space exploration and risk of Parkinson's disease: a perspective review.
NPJ Microgravity 11(1):1
Authors: Nilufar Ali, Afshin Beheshti, Greg Hampikian
Affiliations
- Department of Biological Science, Boise State University, Boise, ID, 83725, USA.
- McGowan Institute for Regenerative Medicine - Center for Space Biomedicine, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
- Department of Biological Science, Boise State University, Boise, ID, 83725, USA.
Abstract
Systemic mitochondrial dysfunction, dopamine loss, sustained structural changes in the basal ganglia including reduced tyrosine hydroxylase, and altered gait- these effects observed in space-flown animals and astronauts mirrors Parkinson's disease (PD). Evidence of mitochondrial changes in space-flown human cells, examined through the lens of PD, suggests that spaceflight-induced PD-like molecular changes are important to monitor during deep space exploration. These changes, may potentially elevate the risk of PD in astronauts.
MeSH
Parkinson Disease, Astronauts