Journal Article Epublish
PubMed: 39765763 DOI: 10.3390/antiox13121434
Healthier Lipid Profiles of Japanese Adults, Especially in Women with Elevated High-Density Lipoprotein Cholesterol (HDL-C), Are Associated with Low HDL-C Peroxide Content.
Antioxidants (Basel) 13(12)
Authors: Loni Berkowitz-Fiebich, Shelby M Flaherty, Shinobu Kitayama, Mayumi Karasawa, Norito Kawakami, Attilio Rigotti, Christopher L Coe
Affiliations
- Departamento de Nutricion Diabetes y Metabolismo, Potificia Universidad Catolica de Chile, Santiago 8320165, Chile.
- Department of Surgery, Duke University, Durham, NC 27708, USA.
- Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA.
- Department of Comparative Psychology, Tokyo Woman's Christian University, Tokyo 167-004, Japan.
- Department of Mental Health, University of Tokyo, Tokyo 113-8654, Japan.
- Department of Psychology, University of Wisconsin-Madison, 1202 West Johnson Street, Madison, WI 53706, USA.
Abstract
Japanese adults typically have healthier lipid profiles than American and European adults and a lower prevalence and later onset of atherosclerotic cardiovascular disease (ASCVD). Many Japanese also have uniquely elevated levels of high-density lipoprotein cholesterol (HDL-C). The following analysis examined the relationship between HDL-C level and HDL-C peroxide content, a bioindicator of unhealthy lipid metabolism in Japanese adults. Blood samples were collected from 463 participants, 31-84 years of age, who lived in Tokyo. A second blood sample was collected 5 years later from 241 of the participants, allowing us to evaluate the temporal stability of the inverse correlation between HDL-C level and HDL-C peroxide content. Glucoregulation and inflammatory activity were assessed because both can be associated with dyslipidemia and HDL-C dysfunction. Obesity and central adiposity were also considered. Overall, women had healthier HDL-C profiles than men. Elevated HDL-C (>90 mg/dL) was common (16.6%) and found more often in women. Higher HDL-C peroxide content was associated with older age and central adiposity and incremented further when HA1c and CRP were higher. When assessed 5 years later, lower HDL-C peroxide content continued to be evident in adults with higher HDL-C. While similar associations have been described for other populations, most Japanese adults typically had healthier levels of HDL-C with lower HDL-C peroxide content than previously reported for American adults.
MeSH
Peroxides, Aging, Lipoproteins, Lipoproteins, Hdl, Adiposity, Cholesterol, Obesity, Sex, Cholesterol, Hdl