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Publications

Journal Article Systematic Review Meta-Analysis Epublish

PubMed: 39766314 DOI: 10.3390/biom14121607

Molecular Pathways Linking High-Fat Diet and PM 2.5 Exposure to Metabolically Abnormal Obesity: A Systematic Review and Meta-Analysis.

Biomolecules 14(12)

Authors: Sagrario Lobato, Víctor Manuel Salomón-Soto, Claudia Magaly Espinosa-Méndez, María Nancy Herrera-Moreno, Beatriz García-Solano, Ernestina Pérez-González, Facundo Comba-Marcó-Del-Pont, Mireya Montesano-Villamil, Marco Antonio Mora-Ramírez, Claudia Mancilla-Simbro, Ramiro Álvarez-Valenzuela

Affiliations

  • Departamento de Investigación en Salud, Servicios de Salud del Estado de Puebla, 603 North 6th Street, Centro Colony, Puebla 72000, Mexico.
  • Clínica de Medicina Familiar con Especialidades y Quirófano ISSSTE, 27 North Street 603, Santa Maria la Rivera Colony, Puebla 72045, Mexico.
  • Educación Superior, Centro de Estudios, "Justo Sierra", Surutato, Badiraguato 80600, Mexico.
  • Facultad de Cultura Física, Benemérita Universidad Autónoma de Puebla, San Claudio Avenue and 22nd South Boulevard, Ciudad Universitaria Colony, Puebla 72560, Mexico.
  • Educación Superior, Centro de Estudios, "Justo Sierra", Surutato, Badiraguato 80600, Mexico. Departamento de Medio Ambiente, Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Unidad Sinaloa, Instituto Politécnico Nacional, Juan de Dios Bátiz Boulevard 250, San Joachin Colony, Guasave 81049, Mexico.
  • Facultad de Enfermería, Benemérita Universidad Autónoma de Puebla, 25th Avenue West 1304, Los Volcanes Colony, Puebla 74167, Mexico.
  • Subsecretaría de Servicios de Salud Zona B, Servicios de Salud del Estado de Puebla, 603 North 6th Street, Centro Colony, Puebla 72000, Mexico.
  • Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, San Claudio Avenue 1814, Ciudad Universitaria Colony, Puebla 72560, Mexico.
  • HybridLab, Fisiología y Biología Molecular de Células Excitables, Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Prolongation of 14th South Street 6301, Ciudad Universitaria Colony, Puebla 72560, Mexico.

Abstract

Obesity, influenced by environmental pollutants, can lead to complex metabolic disruptions. This systematic review and meta-analysis examined the molecular mechanisms underlying metabolically abnormal obesity caused by exposure to a high-fat diet (HFD) and fine particulate matter (PM 2.5). Following the PRISMA guidelines, articles from 2019 to 2024 were gathered from Scopus, Web of Science, and PubMed, and a random-effects meta-analysis was performed, along with subgroup analyses and pathway enrichment analyses. This study was registered in the Open Science Framework. Thirty-three articles, mainly case-control studies and murine models, were reviewed, and they revealed that combined exposure to HFD and PM 2.5 resulted in the greatest weight gain (82.835 g, p = 0.048), alongside increases in high-density lipoproteins, insulin, and the superoxide dismutase. HFD enriched pathways linked to adipocytokine signaling in brown adipose tissue, while PM 2.5 impacted genes associated with fat formation. Both exposures downregulated protein metabolism pathways in white adipose tissue and activated stress-response pathways in cardiac tissue. Peroxisome proliferator-activated receptor and AMP-activated protein kinase signaling pathways in the liver were enriched, influencing non-alcoholic fatty liver disease. These findings highlight that combined exposure to HFD and PM 2.5 amplifies body weight gain, oxidative stress, and metabolic dysfunction, suggesting a synergistic interaction with significant implications for metabolic health.

MeSH

Environmental Pollutants, Stress, Physiological, Weight Gain, Oxidative Stress, Diet, High-Fat, Liver, Diet, Obesity, Tissues, Adipose Tissue