System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Review Research Support, Non-U.S. Gov't Epublish 1 citation

PubMed: 39772122 DOI: 10.3390/v16121811

Neuropsychiatric Burden of SARS-CoV-2: A Review of Its Physiopathology, Underlying Mechanisms, and Management Strategies.

Viruses 16(12)

Authors: Aliteia-Maria Pacnejer, Anca Butuca, Carmen Maximiliana Dobrea, Anca Maria Arseniu, Adina Frum, Felicia Gabriela Gligor, Rares Arseniu, Razvan Constantin Vonica, Andreea Loredana Vonica-Tincu, Cristian Oancea, Cristina Mogosan, Ioana Rada Popa Ilie, Claudiu Morgovan, Cristina Adriana Dehelean

Affiliations

  • Department of Toxicology, Drug Industry, Management and Legislation, Faculty of Pharmacy, "Victor BabeÅŸ" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq. 300041 TimiÅŸoara, Romania.
  • Preclinical Department, Faculty of Medicine, "Lucian Blaga" University of Sibiu, 550169 Sibiu, Romania.
  • County Emergency Clinical Hospital "Pius Brînzeu", 300723 TimiÈ™oara, Romania.
  • Department of Pulmonology, Center for Research and Innovation in Personalized Medicine of Respiratory Diseases, "Victor BabeÅŸ" University of Medicine and Pharmacy, 300041 TimiÈ™oara, Romania.
  • Department of Pharmacology, Physiology and Pathophysiology, Faculty of Pharmacy, "Iuliu HaÅ£ieganu" University of Medicine and Pharmacy, 400029 Cluj-Napoca, Romania.
  • Department of Endocrinology, Faculty of Medicine, "Iuliu HaÅ£ieganu" University of Medicine and Pharmacy, 3-5 Louis Pasteur Street, 400349 Cluj-Napoca, Romania.
  • Research Center for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, "Victor BabeÅŸ" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 TimiÅŸoara, Romania.

Abstract

The COVID-19 outbreak, caused by the SARS-CoV-2 virus, was linked to significant neurological and psychiatric manifestations. This review examines the physiopathological mechanisms underlying these neuropsychiatric outcomes and discusses current management strategies. Primarily a respiratory disease, COVID-19 frequently leads to neurological issues, including cephalalgia and migraines, loss of sensory perception, cerebrovascular accidents, and neurological impairment such as encephalopathy. Lasting neuropsychological effects have also been recorded in individuals following SARS-CoV-2 infection. These include anxiety, depression, and cognitive dysfunction, suggesting a lasting impact on mental health. The neuroinvasive potential of the virus, inflammatory responses, and the role of angiotensin-converting enzyme 2 (ACE2) in neuroinflammation are critical factors in neuropsychiatric COVID-19 manifestations. In addition, the review highlights the importance of monitoring biomarkers to assess Central Nervous System (CNS) involvement. Management strategies for these neuropsychiatric conditions include supportive therapy, antiepileptic drugs, antithrombotic therapy, and psychotropic drugs, emphasizing the need for a multidisciplinary approach. Understanding the long-term neuropsychiatric implications of COVID-19 is essential for developing effective treatment protocols and improving patient outcomes.

MeSH

Sars-Cov-2, Pharmaceutical Preparations, Virology, Drug Therapy, Biomarkers, Covid-19, Viruses, Therapeutics, Severe Acute Respiratory Syndrome-Related Coronavirus

Cited by