Journal Article Review Ppublish
PubMed: 39778593 DOI: 10.1055/a-2512-8928
Application of Network Pharmacology in the Treatment of Neurodegenerative Diseases with Traditional Chinese Medicine.
Planta Med 91(5):226-237
Authors: Qiang Chen, Guanghui Chen, Qianyan Wang
Affiliations
- Department of Pharmacy, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
- Department of Pharmacy, Renmin Hospital, Wuhan University, Wuhan, Hubei, China.
- Liyuan Cardiovascular Center, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Abstract
In recent years, the incidence of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, has exhibited a steadily rising trend, which has posed a major challenge to the global public health. Traditional Chinese medicine, with its multicomponent and multitarget characteristics, offers a promising approach to treating neurodegenerative diseases. However, comprehensively elucidating the complex mechanisms underlying traditional Chinese medicine formulations remains challenging. As an emerging systems biology method, network pharmacology has provided a vital tool for revealing the multitarget mechanisms of traditional Chinese medicine through high-throughput technologies, molecular docking, and network analysis. This paper reviews the advancements in the application of network pharmacology in treating neurodegenerative diseases using traditional Chinese medicine, analyzes the current status of relevant databases and technological methods, discusses the limitations, and proposes future directions to promote the modernization of traditional Chinese medicine and the development of precision medicine.
MeSH
Pharmacology, Medicine, Chinese Traditional, Plants, Medicinal, Therapeutics, Neurodegenerative Diseases