Journal Article Review Ppublish
PubMed: 39779466 DOI: 10.1111/jcmm.70344
Epigenetic Mechanisms in Osteoporosis: Exploring the Power of mA RNA Modification.
J Cell Mol Med 29(1):e70344
Authors: Shuo Tian, Yagang Song, Lin Guo, Hui Zhao, Ming Bai, Mingsan Miao
Affiliations
- Academy of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, China. Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, China.
- School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
- Academy of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
- Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, China.
Abstract
Osteoporosis, recognised as a metabolic disorder, has emerged as a significant burden on global health. Although available treatments have made considerable advancements, they remain inadequately addressed. In recent years, the role of epigenetic mechanisms in skeletal disorders has garnered substantial attention, particularly concerning mA RNA modification. mA is the most prevalent dynamic and reversible modification in eukaryotes, mediating various metabolic processes of mRNAs, including splicing, structural conversion, translation, translocation and degradation and serves as a crucial component of epigenetic modification. Research has increasingly validated that mA plays a vital role in the proliferation, differentiation, migration, invasion,and repair of bone marrow mesenchymal stem cells (BMSCs), osteoblasts and osteoclasts, all of which impact the whole process of osteoporosis pathogenesis. Continuous efforts have been made to target mA regulators and natural products derived from traditional medicine, which exhibit multiple biological activities such as anti-inflammatory and anticancer effects, have emerged as a valuable resources for mA drug discovery. This paper elaborates on mA methylation and its regulatory role in osteoporosis, emphasising its implications for diagnosis and treatment, thereby providing theoretical references.
MeSH
Osteoblasts, Cell Biology, Osteoporosis, Therapeutics, Osteoclasts, Rna