Case Reports Journal Article Epublish
PubMed: 39802876 DOI: 10.62347/PTTF8718
TPM3::NTRK1-rearranged uterine sarcoma: case report and literature review.
Int J Clin Exp Pathol 17(12):477-486
Authors: Yalan Yang, Lei Li
Affiliations
- Department of Pathology, West China Second University Hospital, Sichuan University Chengdu, Sichuan, China. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu, Sichuan, China.
Abstract
Neurotrophic tyrosine kinase receptor (NTRK)-rearranged uterine sarcoma is a rare type of uterine sarcoma. This paper presents a case of a 49-year-old female who was admitted to the hospital due to lower abdominal pain and subsequently diagnosed with tropomyosin 3 (TPM3)::NTRK1-rearranged uterine sarcoma. To our knowledge, TPM3::NTRK1-rearranged sarcomas almost always occur in the cervix, and this is a novel case of uterine corpus occurrence. The patient received chemotherapy and radiotherapy after surgery. No recurrence or metastasis was observed after 9 months of treatment. Moreover, all reported clinicopathological features, treatment methods, and prognoses of NTRK-rearranged uterine sarcoma patients are reviewed herein.
MeSH
Sarcoma, Therapeutics