Journal Article Review Ppublish 7 citations
PubMed: 39809571 DOI: 10.1093/femsre/fuaf001
The impact of phenotypic heterogeneity on fungal pathogenicity and drug resistance.
FEMS Microbiol Rev 49
Authors: Lukasz Kozubowski, Judith Berman
Affiliations
- Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC, 29634, USA.
- Shmunis School of Biomedical and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.
Abstract
Phenotypic heterogeneity in genetically clonal populations facilitates cellular adaptation to adverse environmental conditions while enabling a return to the basal physiological state. It also plays a crucial role in pathogenicity and the acquisition of drug resistance in unicellular organisms and cancer cells, yet the exact contributing factors remain elusive. In this review, we outline the current state of understanding concerning the contribution of phenotypic heterogeneity to fungal pathogenesis and antifungal drug resistance.
MeSH
Pharmaceutical Preparations, Microbiology, Fungi, Drug Resistance
Cited by
- Editorial: In commemoration of the bicentennial of the birth of Louis Pasteur. FEMS Microbiol Rev, 2025
- Fungi and cancer: unveiling the complex role of fungal infections in tumor biology and therapeutic resistance. Front Cell Infect Microbiol, 2025