Journal Article Epublish 5 citations
PubMed: 39816695 DOI: 10.7150/thno.102569
Multiple crosslinked, self-healing, and shape-adaptable hydrogel laden with pain-relieving chitosan@borneol nanoparticles for infected burn wound healing.
Theranostics 15(4):1439-1455
Authors: Zexing Deng, Yi Guo, Xuefeng Wang, Jiajie Song, Guan Yang, Litong Shen, Yuheng Wang, Xin Zhao, Baolin Guo, Wen Wang
Affiliations
- Department of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, Shaanxi, China. College of Materials Science and Engineering, Xi'an University of Science and Technology, Xi'an, 710054, China.
- Shaanxi Key Laboratory of Brain Disorders, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, 710021, China.
- Department of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, Shaanxi, China. Pilot Selection Bureau of PLA Air Force, Beijing, 100195, China.
- Department of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, Shaanxi, China.
- College of Materials Science and Engineering, Xi'an University of Science and Technology, Xi'an, 710054, China.
- State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
- State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710049, China.
Abstract
Next-generation wound dressings with multiple biological functions hold promise for addressing the complications and pain associated with burn wounds. A hydrogel wound dressing loaded with a pain-relieving drug was developed for treating infected burn wounds. Polyvinyl alcohol chemically grafted with gallic acid (PVA-GA), sodium alginate chemically grafted with 3-aminobenzeneboronic acid (SA-PBA), Zn, and chitosan-coated borneol nanoparticles with anti-inflammatory and pain-relieving activities were combined to afford a nanoparticle-loaded hydrogel with a PVA-GA/Zn/SA-PBA network crosslinked via multiple physicochemical interactions. The developed hydrogel demonstrated adhesiveness, self-healing, shape adaptability, injectability, degradability, conformity to complicated wound surfaces, and other desirable biological functions, including a pH-responsive drug release behavior and antibacterial, antioxidant, anti-inflammatory, and proangiogenic activities. In a murine scald wound model, the hydrogel effectively prevented infection by and downregulated pain perception (measured using mouse grimace scale scores and hind paw lifting and licking times), thereby accelerating wound healing. This study provides broad prospects for the development of new hydrogel systems that can substantially improve the dynamic management of infected burn wounds.
MeSH
Hydrogel, Polyethylene Glycol Dimethacrylate, Hydrogels, Nanomedicine, Nanoparticles, Pain, Pharmaceutical Preparations, Chitosan, Burns