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Publications

Journal Article Review Epublish 2 citations

PubMed: 39822783 DOI: 10.4317/jced.62242

Mesenchymal stem cell therapies evidence in the treatment of irradiated salivary glands: A scoping review.

J Clin Exp Dent 16(12):e1547-e1554

Authors: Maria Stella Moreira, Maria Emília Mota, Suely Kunimi Kubo Ariga, Graziella Chagas Jaguar, Márcia Martins Marques

Affiliations

  • Department of Stomatology, A.C. Camargo Cancer Center, São Paulo, SP, Brazil.
  • Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, SP, Brazil.
  • School of Medicine, Emergency Medicine Laboratory, University of São Paulo, São Paulo, SP, Brazil.
  • AALZ, Sigmund Freud University, Vienna, Austria.

Abstract

Background

Radiotherapy is one of the main treatments for head and neck cancer; however, due to its non-selectivity the glandular tissue can be affected. This scoping review aimed to identify the evidence about mesenchymal stem cell therapies for irradiated salivary gland regeneration.

Material and Methods

Two independent reviewers performed a literature search in MEDLINE/PubMed, Scopus, and Web of Science. The inclusion criteria were: 1) studies evaluation regeneration of irradiated salivary glands by stem cell therapies (cell-based or cell-free), (2) studies.

Results

The search resulted in 13 included studies. In general, both therapies demonstrated increased salivary levels, with mucin and amylase increased and structural protection of acinar cells. The cell-free therapy based on labial glands stem cell extract demonstrated a higher number of parasympathetic nerves.

Conclusions

Stem cell therapies (cell-free and cell-based) appear promising strategies for recovering saliva production in patients presenting irradiation-induced hyposalivation, with positive results toward regeneration of the form and function of the glands. However, due to the scarcity and heterogenicity of these pre-clinical studies, it is not possible to indicate which is the more indicated therapy. Mesenchymal stem cells, extracellular vesicles, exosomes, salivary glands, stem cell biology, hyposalivation, radiotherapy.

MeSH

Cells, Xerostomia, Microscopy, Electron, Scanning Transmission, Salivary Glands, Stem Cells, Mesenchymal Stem Cells, Therapeutics