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Publications

Journal Article Review Epublish 2 citations

PubMed: 39822993 DOI: 10.1515/med-2024-1091

Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments.

Open Med (Wars) 20(1):20241091

Authors: Xueting Yu, Huimei He, Jie Wen, Xiuyuan Xu, Zhaojuan Ruan, Rui Hu, Fang Wang, Haibing Ju

Affiliations

  • Endocrine Department, 920th Hospital of Joint Logistics Support Force, PLA, Kunming, 650000, Yunnan, China.
  • Executive Ward Department, 920th Hospital of Joint Logistics Support Force, PLA, Kunming, 650000, Yunnan, China.
  • Department of Hematology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650000, Yunnan, China.
  • Endocrine Department, 920th Hospital of Joint Logistics Support Force, PLA, No. 212 Daguan Road, Xishan District, Kunming, 650000, Yunnan, China.

Abstract

Background

Diabetes-related cognitive impairment is increasingly recognized as a significant complication, profoundly impacting patients' quality of life. This review aims to examine the pathophysiological mechanisms, clinical manifestations, risk factors, assessment and diagnosis, management strategies, and future research directions of cognitive impairment in diabetes.

Methodology

A comprehensive literature search was conducted using PubMed, Medline, and other medical databases to identify, review, and evaluate published articles on cognitive impairment in diabetes. The search focused on studies examining pathophysiology, clinical presentations, risk factors, diagnostic approaches, and management strategies.

Results

The review of current literature revealed that chronic hyperglycemia, insulin resistance, and vascular factors are major contributing factors to cognitive deficits in diabetes. Clinical manifestations include impairments in attention, memory, executive function, visuospatial abilities, and language. Risk factors encompass disease duration, glycemic control, presence of complications, age, education level, and comorbidities. Assessment tools include cognitive screening instruments, neuropsychological testing, and neuroimaging techniques. Management strategies involve glycemic control optimization, lifestyle modifications, cognitive training, and pharmacological interventions.

Conclusion

This review highlights the significant prevalence and impact of cognitive impairment in diabetes, resulting from complex metabolic and vascular disturbances. Early detection and multifaceted interventions are crucial for preserving cognitive function and improving patient outcomes. Future research should focus on neuroprotective strategies, biomarker identification, and personalized approaches. Collaborative efforts between clinicians and researchers are essential to effectively address this growing healthcare challenge and enhance the quality of life for individuals with diabetes-related cognitive impairment.

MeSH

Diabetes Mellitus, Quality Of Life, Hyperglycemia, Neuroprotection, Executive Function, Cognitive Dysfunction, Signs And Symptoms, Cognition Disorders, Risk Factors, Research, Therapeutics, Glycemic Control

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