Journal Article Review Epublish 15 citations
PubMed: 39840075 DOI: 10.3389/fmolb.2024.1499104
Review of cancer cell volatile organic compounds: their metabolism and evolution.
Front Mol Biosci 11:1499104
Authors: Takeshi Furuhashi, Kanako Toda, Wolfram Weckwerth
Affiliations
- NUS Environmental Research Institute, National University of Singapore, Singapore, Singapore.
- Department of Oral Health Sciences, Health Sciences, Saitama Prefectural University, Koshigaya-shi, Japan.
- Vienna Metabolomics Center (VIME), University of Vienna, Vienna, Austria.
- Molecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.
- Health in Society Research Network, University of Vienna, Vienna, Austria.
Abstract
Cancer is ranked as the top cause of premature mortality. Volatile organic compounds (VOCs) are produced from catalytic peroxidation by reactive oxygen species (ROS) and have become a highly attractive non-invasive cancer screening approach. For future clinical applications, however, the correlation between cancer hallmarks and cancer-specific VOCs requires further study. This review discusses and compares cellular metabolism, signal transduction as well as mitochondrial metabolite translocation in view of cancer evolution and the basic biology of VOCs production. Certain cancerous characteristics as well as the origin of the ROS removal system date back to procaryotes and early eukaryotes and share commonalities with non-cancerous proliferative cells. This calls for future studies on metabolic cross talks and regulation of the VOCs production pathway.
MeSH
Cells, Neoplasms, Volatile Organic Compounds, Multifunctional Enzymes