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Journal Article Epublish 11 citations

PubMed: 39841690 DOI: 10.1371/journal.pone.0313504

Respiratory virus detections in children presenting to an Australian paediatric referral hospital pre-COVID-19 pandemic, January 2014 to December 2019.

PLoS One 20(1):e0313504

Authors: Rebecca Burrell, Gemma L Saravanos, Alison Kesson, Kin-Chuen Leung, Alex C Outhred, Nicholas Wood, David Muscatello, Philip N Britton

Affiliations

  • Sydney Medical School, University of Sydney, Sydney, New South Wales (NSW), Australia.
  • Centre for Paediatric and Perinatal Infection Research, The Children's Hospital at Westmead, Westmead, NSW, Australia.
  • The University of Sydney Infectious Diseases Institute (Sydney ID), University of Sydney, Sydney, NSW, Australia.
  • Susan Wakil School of Nursing and Midwifery, University of Sydney, Sydney, NSW, Australia.
  • Department of Infectious Diseases & Microbiology, The Children's Hospital at Westmead, Westmead, NSW, Australia.
  • Sydney Medical School, University of Sydney, Sydney, New South Wales (NSW), Australia. The University of Sydney Infectious Diseases Institute (Sydney ID), University of Sydney, Sydney, NSW, Australia. Department of Infectious Diseases & Microbiology, The Children's Hospital at Westmead, Westmead, NSW, Australia.
  • School of Population Health, University of New South Wales, Sydney, NSW, Australia.

Abstract

Acute respiratory infections cause significant paediatric morbidity, but for pathogens other than influenza, respiratory syncytial virus (RSV), and SARS-CoV-2, systematic monitoring is not commonly performed. This retrospective analysis of six years of routinely collected respiratory pathogen multiplex PCR testing at a major paediatric hospital in New South Wales Australia, describes the epidemiology, year-round seasonality, and co-detection patterns of 15 viral respiratory pathogens. 32,599 respiratory samples from children aged under 16 years were analysed. Most samples were associated with a hospital admission (24,149, 74.1%) and the median age of sampling was 16 months (IQR 5-53). Viruses were detected in 62.9% (20,510) of samples, with single virus detections occurring in 73.5% (15,082) of positive samples. In instances of single virus detection, rhinovirus was most frequent (5125, 40.6%), followed by RSV-B (1394, 9.2%) and RSV-A (1290, 8.6%). Moderate to strong seasonal strength was observed for most viruses with some notable exceptions. Rhinovirus and enterovirus were detected year-round and low seasonal strength was observed for adenovirus and bocavirus. Biennial seasonal patterns were observed for influenza B and parainfluenza virus 2. Co-detections occurred in 5,428 samples, predominantly with two (4284, 79.0%) or three viruses (904, 16.7%). The most common co-detections were rhinovirus-adenovirus (566, 10.4%), rhinovirus-enterovirus (357, 8.3%), and rhinovirus-RSV-B (337, 7.9%). Ongoing pan-pathogen surveillance, integrating both laboratory and clinical data, is necessary to assist in identification of key pathogens and combination of pathogens to support effective preventative public health strategies and reduce the burden of paediatric respiratory infections.

MeSH

Respiratory Syncytial Viruses, Adenoviridae, Respiratory Tract Infections, Rhinovirus, Covid-19, Influenza, Human, Viruses, Pandemics, Enterovirus, Infections, Child

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