Journal Article Review Epublish 3 citations
PubMed: 39845771 DOI: 10.2147/IJN.S504629
Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment.
Int J Nanomedicine 20:705-721
Authors: Yunheng Liu, Longqing Si, Yuxuan Jiang, Shaojing Jiang, Xiaokang Zhang, Song Li, Jing Chen, Jinghui Hu
Affiliations
- School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, 264003, People's Republic of China.
- Yantai Engineering Research Center for Digital Technology of Stomatology, Characteristic Laboratories of Colleges and Universities in Shandong Province for Digital Stomatology, Institute of Stomatology, Binzhou Medical University, Yantai, 264003, People's Republic of China.
Abstract
The metabolic activity of tumor cells leads to the acidification of the surrounding microenvironment, which provides new strategies for the application of nanotechnology in cancer therapy. Researchers have developed various types of pH-responsive nanomaterials based on the tumor acidic microenvironment. This review provides an in-depth discussion on the design mechanisms, drug-loading strategies, and application pathways of tumor acidic microenvironment-responsive nanodrug delivery systems. These materials trigger drug release upon reaching the tumor microenvironment, enhancing therapeutic targeting and reducing toxicity to healthy cells. pH-responsive nanomaterials include organic nanomaterials, inorganic nanomaterials, and composite nanomaterials. Additionally, this review outlines the drug-loading strategies, application prospects, and challenges of pH-responsive nanomaterials, aiming to promote the development and clinical translation of this field.
MeSH
Cells, Nanomedicine, Pharmaceutical Preparations, Neoplasms, Nanostructures, Drug Delivery Systems, Therapeutics, Tumor Microenvironment