Journal Article Epublish 1 citation
PubMed: 39857651 DOI: 10.3390/biomedicines13010067
Bariatric Surgery as a Molecular Modulator: The Role of FSHR Polymorphisms in Enhancing eNOS Expression and Reproductive Hormone Dynamics in Women with Severe Obesity.
Biomedicines 13(1)
Authors: Charalampos Voros, Despoina Mavrogianni, Kyriakos Bananis, Alexios Karakasis, Anthi-Maria Papahliou, Vasileios Topalis, Antonia Varthaliti, Raphail Mantzioros, Panagiota Kondili, Menelaos Darlas, Regina Sotiropoulou, Diamantis Athanasiou, Dimitris Mathiopoulos, Panagiotis Antsaklis, Dimitrios Loutradis, Georgios Daskalakis
Affiliations
- 1st Department of Obstetrics and Gynecology, 'Alexandra' General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece.
- King's College Hospitals NHS Foundation Trust, London SE5 9RS, UK.
- Department of Internal Medicine, Hospital of Thun, 3600 Thun, Switzerland.
- IVF Athens Reproduction Center V. Athanasiou, 15123 Maroussi, Greece.
- Rea Maternity Hospital S.A. Avenue Siggrou 383 & Pentelis 17, P. Faliro, 17564 Athens, Greece.
- Fertility Institute-Assisted Reproduction Unit, Paster 15, 11528 Athens, Greece.
- Athens Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece.
Abstract
BACKGROUND/OBJECTIVES
Severe obesity (BMI > 40 kg/m) has a severe influence on vascular health and reproduction. This study looks at how bariatric surgery affects endothelial nitric oxide synthase (eNOS) expression and reproductive hormone regulation across different follicle-stimulating hormone receptor (FSHR) polymorphism groups in women with extreme obesity.
METHODS
Twenty-nine women with extreme obesity had bariatric surgery. Pre- and post-surgery levels of eNOS and reproductive hormones such as follicle-stimulating hormone (FSH), sex hormone-binding globulin (SHBG), anti-Müllerian hormone (AMH), and antral follicle count (AFC) were assessed. Patients were divided into three FSHR polymorphism groups (Ser/Ser, Asn/Asn, and Ser/Asn), and results were compared between them. Statistical techniques were used to determine changes and relationships.
RESULTS
Bariatric surgery led to substantial increases in eNOS expression across all FSHR polymorphism groups ( < 0.0001), with the Ser/Ser group exhibiting the most variability. Prior to surgery, the Ser/Ser group had substantially higher FSH levels (7.41 ± 0.60 mIU/mL) than the Asn/Asn group (5.20 ± 0.63 mIU/mL, < 0.001). Following surgery, FSH levels rose in the Ser/Ser group (9.45 ± 0.87 mIU/mL), with significant differences between the Ser/Ser and Ser/Asn groups (mean difference = 0.97, = 0.019). SHBG levels had a negative connection with eNOS expression after surgery (r = -0.365, = 0.049). AMH and AFC remained constant throughout polymorphism groups. BMI decreased uniformly, with an average of 15.2 ± 1.8 kg six months after surgery.
CONCLUSIONS
Bariatric surgery improves vascular health and regulates reproductive hormones, especially in individuals with the Ser/Ser genotype. These findings indicate the possibility of combining genetic testing and bariatric therapies to improve infertility treatment in obese women.
MeSH
Follicle Stimulating Hormone, Infertility, Hormones, Bariatric Surgery, Obesity, Therapeutics, Obesity, Morbid, Vascular Health