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Journal Article Journal Article Epublish 2 citations

PubMed: 39859108 DOI: 10.3390/medicina61010126

Probiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative Approach.

Medicina (Kaunas) 61(1)

Authors: Liliana Sachelarie, Ioana Scrobota, Ioana Romanul, Raluca Iurcov, Georgiana Ioana Potra Cicalau, Liana Todor

Affiliations

  • Department of Preclinical Discipline, Faculty of Medicine, Apollonia University, 700511 Iasi, Romania.
  • Department of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 10 1st Decembrie Street, 410073 Oradea, Romania.

Abstract

: Periodontal inflammation, often linked to oral microbiota dysbiosis dominated by pathogenic bacteria, remains a significant challenge in periodontitis management. Traditional periodontal therapies primarily reduce the bacterial load but fail to restore the microbiota balance. Probiotics offer a promising therapeutic adjunct with their ability to enhance beneficial bacteria. This study investigates the effects of probiotics on the oral microbiota, inflammatory markers (IL-1β, TNF-α), and clinical parameters (gingival index, bleeding index, and periodontal pocket depth). : In this pilot study, 80 patients with moderate-to-severe periodontitis were assigned to two groups. Group A received standard periodontal therapy (non-surgical periodontal therapy (NSPT)) with probiotic supplementation (, 2 × 10⁹ CFU daily for 8 weeks), and Group B received standard treatment with a placebo. Microbiological changes were assessed via quantitative PCR, while inflammatory markers (IL-1β, TNF-α) were analyzed using ELISA. Clinical parameters, including the gingival index (GI), bleeding index (BI), and periodontal pocket depth (PPD), were measured at baseline (T0), 4 weeks (T1), and 8 weeks (T2) using standardized methods. : Probiotic therapy (Group A) significantly reduced the pathogenic bacteria and increased the beneficial bacteria levels compared to the placebo ( < 0.01). Inflammatory markers decreased by 37% (IL-1β) and 42% (TNF-α), while clinical parameters improved, with reductions in the gingival and bleeding indices (-1.5, -1.3) and a 2 mm decrease in the periodontal pocket depth ( < 0.01). : Probiotics, as an adjunct to periodontal therapy, effectively restore the microbiota balance, reduce inflammation, and improve clinical outcomes in periodontitis.

MeSH

Hemorrhage, Periodontal Pocket, Periodontal Diseases, Probiotics, Therapeutics, Periodontitis, Bacteria, Microbiota, Oral Microbiome

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