Journal Article Review Research Support, Non-U.S. Gov't Epublish
PubMed: 39861887 DOI: 10.3390/v17010098
Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19.
Viruses 17(1)
Authors: Abigail Vanderheiden, Michael S Diamond
Affiliations
- Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
- Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
- Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
- The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA.
- Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO 63110, USA.
Abstract
Post-acute sequelae of COVID-19 (PASC) are a diverse set of symptoms and syndromes driven by dysfunction of multiple organ systems that can persist for years and negatively impact the quality of life for millions of individuals. We currently lack specific therapeutics for patients with PASC, due in part to an incomplete understanding of its pathogenesis, especially for non-pulmonary sequelae. Here, we discuss three animal models that have been utilized to investigate PASC: non-human primates (NHPs), hamsters, and mice. We focus on neurological, gastrointestinal, and cardiovascular PASC and highlight advances in mechanistic insight that have been made using these animal models, as well as discussing the sequelae that warrant continued and intensive research.
MeSH
Coronavirus, Heart, Virology, Brain, Gastrointestinal Tract, Covid-19