Journal Article Review Epublish
PubMed: 39867458 DOI: 10.1016/j.jtauto.2025.100267
Iron metabolism in rheumatic diseases.
J Transl Autoimmun 10:100267
Authors: Aliakbar Givian, Amin Azizan, Ahmadreza Jamshidi, Mahdi Mahmoudi, Elham Farhadi
Affiliations
- Rheumatology Research Center, Tehran University of Medical Science, Tehran, Iran. Department of Immunology, School of Medicine, Semnan University of Medical Science, Semnan, Iran.
- Rheumatology Research Center, Tehran University of Medical Science, Tehran, Iran.
- Research Center for Chronic Inflammatory Diseases, Tehran University of Medical Sciences, Tehran, Iran.
Abstract
Iron is a crucial element for living organism in terms of oxygen transport, hematopoiesis, enzymatic activity, mitochondrial respiratory chain function and also immune system function. The human being has evolved a mechanism to regulate body iron. In some rheumatic diseases such as rheumatoid arthritis (RA), systemic lupus erythematous (SLE), systemic sclerosis (SSc), ankylosing spondylitis (AS), and gout, this balanced iron regulation is impaired. Altered iron homeostasis can contribute to disease progression through ROS production, fibrosis, inflammation, abnormal bone homeostasis, NETosis and cell senescence. In this review, we have focused on the iron metabolism in rheumatic disease and its role in disease progression.
MeSH
Homeostasis, Disease Progression, Rheumatic Diseases
Cited by
- Trace Elements-Role in Joint Function and Impact on Joint Diseases. Int J Mol Sci, 2025