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Publications

Journal Article Ppublish 3 citations

PubMed: 39869456 DOI: 10.1093/brain/awaf022

White matter connections within the central sulcus subserving the somato-cognitive action network.

Brain 148(5):1789-1800

Authors: Georgios P Skandalakis, Luca ViganĂ², Clemens Neudorfer, Marco Rossi, Luca Fornia, Gabriella Cerri, Kelsey P Kinsman, Zabiullah Bajouri, Armin D Tavakkoli, Christos Koutsarnakis, Evgenia Lani, Spyridon Komaitis, George Stranjalis, Gelareh Zadeh, Jessica Barrios-Martinez, Fang-Cheng Yeh, Demitre Serletis, Michael Kogan, Constantinos G Hadjipanayis, Jennifer Hong, Nathan Simmons, Evan M Gordon, Nico U F Dosenbach, Andreas Horn, Lorenzo Bello, Aristotelis Kalyvas, Linton T Evans

Affiliations

  • Department of Surgery, Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA.
  • Department of Medical Biotechnology and Translational Medicine, MoCA Laboratory, University of Milan, IRCCS Galeazzi Sant'Ambrogio, 20157 Milan, Italy.
  • Department of Neurology Brigham & Women's Hospital, Center for Brain Circuit Therapeutics, Harvard Medical School, Boston, MA 02115, USA.
  • MGH Neurosurgery & Center for Neurotechnology and Neurorecovery (CNTR) at MGH Neurology Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Department of Neurology, Movement Disorder and Neuromodulation Unit, CharitĂ©-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.
  • Department of Medical Biotechnology and Translational Medicine, Neurosurgical Oncology Unit, University of Milan, IRCCS Galeazzi Sant'Ambrogio, 20157 Milan, Italy.
  • Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.
  • Department of Neurosurgery, National and Kapodistrian University of Athens, School of Medicine, Athens 11527, Greece.
  • Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada, M5T 1P5.
  • Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  • Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA.
  • Cleveland Clinic Epilepsy Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
  • Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
  • Department of Neurosurgery, University of New Mexico Hospital, Albuquerque, NM 87131, USA.
  • Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
  • Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO 63130, USA.
  • Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Department of Oncology and Haemato-Oncology, Neurosurgical Oncology Unit, University of Milan, IRCCS Galeazzi Sant'Ambrogio, 20161 Milan, Italy.

Abstract

The somato-cognitive action network (SCAN) consists of three nodes interspersed within Penfield's motor effector regions. The configuration of the somato-cognitive action network nodes resembles the one of the 'plis de passage' of the central sulcus: small gyri bridging the precentral and postcentral gyri. Thus, we hypothesize that these may provide a structural substrate of the somato-cognitive action network. Using microdissections of 16 human hemispheres, we consistently identified a chain of three distinct plis de passage with increased underlying white matter in locations analogous to the somato-cognitive action network nodes. We mapped localizations of plis de passage into standard stereotactic space to seed functional MRI connectivity across 9000 resting-state functional MRI scans, which demonstrated the connectivity of these sites with the somato-cognitive action network. Intraoperative recordings during direct electrical central sulcus stimulation further identified inter-effector regions corresponding to plis de passage locations. This work provides a critical step towards an improved understanding of the somato-cognitive action network in both structural and functional terms. Furthermore, our work has the potential to guide the development of refined motor cortex stimulation techniques for treating brain disorders and operative resective techniques for complex surgery of the motor cortex.

MeSH

White Matter, Motor Cortex, Work, Neurology

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