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Publications

Journal Article Ppublish

PubMed: 39887249 DOI: 10.1128/jvi.01685-24

mRNA vaccine-induced SARS-CoV-2 spike-specific IFN-γ and IL-2 T-cell responses are predictive of serological neutralization and are transiently enhanced by pre-existing cross-reactive immunity.

J Virol 99(3):e0168524

Authors: Philip Samaan, Chapin S Korosec, Patrick Budylowski, Serena L L Chau, Adrian Pasculescu, Freda Qi, Melanie Delgado-Brand, Tulunay R Tursun, Geneviève Mailhot, Roya Monica Dayam, Corey R Arnold, Marc-André Langlois, Justin Mendoza, Thomas Morningstar, Ryan Law, Erik Mihelic, Salma Sheikh-Mohamed, Eric Yixiao Cao, Nimitha Paul, Anjali Patel, Keelia Quinn de Launay, Jamie M Boyd, Alyson Takaoka, Karen Colwill, Vitaliy Matveev, Feng Yun Yue, Allison McGeer, Sharon Straus, Anne-Claude Gingras, Jane M Heffernen, Mario Ostrowski

Affiliations

  • Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Modelling Infection and Immunity Lab, Mathematics and Statistics, York University, Toronto, Ontario, Canada.
  • Center for Disease Modelling, Mathematics and Statistics, York University, Toronto, Ontario, Canada.
  • Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
  • Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada.
  • Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
  • Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
  • Unity Health Toronto, St Michael's Hospital, Toronto, Ontario, Canada.
  • Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  • Keenan Research Center for Biomedical Science, St Michael's Hospital Keenan, Toronto, Ontario, Canada.

MeSH

Interferon-Gamma, Immunity, Humoral, Cells, Coronavirus, Sars-Cov-2, Vaccines, Severe Acute Respiratory Syndrome, Rna, Messenger, Antibodies, Neutralizing, Vaccination, Immunoglobulin A, Viruses, Immunity, Interleukin-2, Severe Acute Respiratory Syndrome-Related Coronavirus, T-Lymphocytes