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Publications

Journal Article Ppublish

PubMed: 39895344 DOI: 10.1093/hmg/ddae195

Decomposing the genetic background of chronic back pain.

Hum Mol Genet 34(8):711-725

Authors: Elizaveta E Elgaeva, Irina V Zorkoltseva, Arina V Nostaeva, Dmitrii A Verzun, Evgeny S Tiys, Anna N Timoshchuk, Anatoliy V Kirichenko, Gulnara R Svishcheva, Maxim B Freidin, Frances M K Williams, Pradeep Suri, Yurii S Aulchenko, Tatiana I Axenovich, Yakov A Tsepilov

Affiliations

  • Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 10, Ac. Lavrentieva ave. 630090, Novosibirsk, Russia.
  • Novosibirsk State University, 1, Pirogova str. 630090, Novosibirsk, Russia.
  • Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 10, Ac. Lavrentieva ave. 630090, Novosibirsk, Russia. Novosibirsk State University, 1, Pirogova str. 630090, Novosibirsk, Russia.
  • MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, 27, building 1, Lomonosovsky ave. 119991, Moscow, Russia.
  • Moscow Institute of Physics and Technology, 9, Institutsky lane, 141700, Dolgoprudny, Russia.
  • Vavilov Institute of General Genetics, RAS, 3, Gubkin str. 119991, Moscow, Russia.
  • Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, Westminster Bridge Rd. SE1 7EH, London, UK.
  • Department of Rehabilitation Medicine, University of Washington, 325, Ninth ave. WA 98104, Seattle, USA.
  • VA Puget Sound Health Care System, 1660, South Columbian Way, WA 98108, Seattle, USA.
  • PolyOmica, 61, Het Vlaggeschip, 5237 PA, 's-Hertogenbosch, The Netherlands.

Abstract

Chronic back pain (CBP) is a disabling condition with a lifetime prevalence of 40% and a substantial socioeconomic burden. Because of the high heterogeneity of CBP, subphenotyping may help to improve prediction and support personalized treatment of CBP. To investigate CBP subphenotypes, we decomposed its genetic background into a shared one common to other chronic pain conditions (back, neck, hip, knee, stomach, and head pain) and unshared genetic background specific to CBP. We identified and replicated 18 genes with shared impact across different chronic pain conditions and two genes that were specific for CBP. Among people with CBP, we demonstrated that polygenic risk scores accounting for the shared and unshared genetic backgrounds of CBP may underpin different CBP subphenotypes. These subphenotypes are characterized by varying genetic predisposition to diverse medical conditions and interventions such as diabetes mellitus, myocardial infarction, diagnostic endoscopic procedures, and surgery involving muscles, bones, and joints.

MeSH

Diabetes Mellitus, Genes, Low Back Pain, Chronic Pain, Pain, Cytogenetics, Back Pain, Genetic Background, Genetics, Medical, Genetic Risk Score