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Journal Article Epublish 1 citation

PubMed: 39906594 DOI: 10.1016/j.jacbts.2024.08.011

A 6-Minute Limb Function Assessment for Therapeutic Testing in Experimental Peripheral Artery Disease Models.

JACC Basic Transl Sci 10(1):88-103

Authors: Victoria R Palzkill, Jianna Tan, Divyansha Moparthy, Abigail L Tice, Leonardo F Ferreira, Terence E Ryan

Affiliations

  • Department of Applied Physiology and Kinesiology, The University of Florida, Gainesville, Florida, USA.
  • Center for Exercise Science, The University of Florida, Gainesville, Florida, USA.
  • The Myology Institute, The University of Florida, Gainesville, Florida, USA.
  • Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina, USA.

Abstract

In this study, we present a novel 6-minute limb function test that allows for the congruent assessment of muscular performance and hemodynamics in preclinical models of peripheral artery disease. Using several experimental conditions, the results demonstrate the superior efficacy of the 6-minute limb function test to detect differences in the response to hindlimb ischemia across several interventions, including where traditional perfusion recovery, capillary density, and muscle strength measures were unable to detect interventional differences, thus allowing for more rigorous assessment of preclinical therapies before clinical translation.

MeSH

Research Design, Arteries, Peripheral Arterial Disease, Therapeutics

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