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Journal Article Observational Study Multicenter Study Ppublish 11 citations

PubMed: 39907319 DOI: 10.1093/infdis/jiaf056

Ten-Year Surveillance of Respiratory Syncytial Virus Hospitalizations in Adults: Incidence Rates and Case Definition Implications.

J Infect Dis 231(5):e830-e839

Authors: Arantxa Urchueguía-Fornes, Cintia Muñoz-Quiles, Ainara Mira-Iglesias, Mónica López-Lacort, Beatriz Mengual-Chuliá, F Xavier López-Labrador, Javier Díez-Domingo, Alejandro Orrico-Sánchez

Affiliations

  • Vaccines Research Unit, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO-Public Health, Valencia, Spain.
  • CIBER de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain.
  • Vaccines Research Unit, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO-Public Health, Valencia, Spain. CIBER de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain.
  • Virology Laboratory, Genomics and Health Area, Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO-Public Health, Valencia, Spain.
  • Universidad Católica de Valencia San Vicente Mártir, Chair of Vaccines, Valencia, Spain.
  • Vaccines Research Unit, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO-Public Health, Valencia, Spain. CIBER de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain. Universidad Católica de Valencia San Vicente Mártir, Chair of Vaccines, Valencia, Spain.

Abstract

BACKGROUND

The impact of respiratory syncytial virus (RSV) in older adults is underrecognized, and the limited existing studies on the incidence of hospitalizations show great variability. This study aims to estimate the seasonal incidence rates (IRs) of RSV hospitalizations among adults aged ≥60 years and evaluate how different case definitions influence these estimates.

METHODS

A prospective, multicenter observational study with active monitoring was conducted over 10 seasons (2010-2011 to 2019-2020) in 4-10 hospitals (depending on the season) and covered 21%-46% of the region's total population (about 5 million people). RSV hospitalization IRs per 100 000 person-years and 95% confidence intervals were calculated with the exact Poisson method and were stratified by age group (≥60, ≥70, or ≥80 years), RSV season, sex, and the entire study period. Two case definitions were compared: influenzalike illness (ILI) and the combined use of ILI and extended severe acute respiratory infection (ILI/SARI).

RESULTS

A total of 40 600 hospitalizations of individuals aged ≥60 years were included. The RSV hospitalization IRs ranged from 21 to 402 per 100 000 person-years, varying by season, age group, and case definition. The highest IRs were observed in those aged ≥80 years. The ILI case definition underestimated RSV hospitalizations by 13%-40% when compared with the ILI/SARI case definition.

CONCLUSIONS

On average, approximately 1 in every 1000 adults aged ≥60 years is hospitalized due to RSV. The risk of a severe RSV infection increases with age and varies significantly between seasons. These are key results for the estimation of the potential impact of the new available RSV vaccines.

MeSH

Respiratory Syncytial Viruses, Hospitalization, Incidence, Aged, Viruses, Communicable Diseases, Infections

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