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Publications

Journal Article Epublish

PubMed: 39920379 DOI: 10.1007/s11306-024-02217-9

Unveiling the metabolomic profile of growth hormone deficiency children using NMR spectroscopy.

Metabolomics 21(1):25

Authors: Eftychia A Aggelaki, Aristeidis Giannakopoulos, Panagiota D Georgiopoulou, Styliani A Chasapi, Alexandra Efthymiadou, Dimitra Kritikou, Dionisios Chrysis, Georgios A Spyroulias

Affiliations

  • Department of Pharmacy, School of Health Sciences, University of Patras, 26504, Rio, Greece.
  • Division of Endocrinology Department of Pediatrics, Medical School, University of Patras, 26504, Rio, Greece.
  • Division of Endocrinology Department of Pediatrics, Medical School, University of Patras, 26504, Rio, Greece.
  • Department of Pharmacy, School of Health Sciences, University of Patras, 26504, Rio, Greece.

Abstract

INTRODUCTION

The diagnosis of Growth Hormone Deficiency (GHD) during childhood has been the subject of much controversy over the last few years. Aiming to accurate medical treatment, there is a need for biomarker discovery.

OBJECTIVE

To characterize the metabolic profile of GHD children, examine the effect of GH administration on the metabolic signature, and investigate the correlations between metabolites and IGF-1.

METHODS

Nuclear Magnetic Resonance (NMR)-based untargeted and targeted metabolomic approach applied to study the metabolic profiles of children with GHD. Plasma, serum, and urine samples were collected from twenty-two children diagnosed with GHD and forty-eight age matched controls from the Pediatric Endocrinology Unit of the University Hospital of Patras. Experimental data were examined by both multivariate and univariate statistical analysis.

RESULTS

The results of this pilot study revealed a different metabolic fingerprint of children with GHD in comparison to age-matched healthy individuals. However, the detected alterations in the metabolite patterns before and after GH treatment were subtle and of minor discriminative statistical power.

CONCLUSIONS

This study provides evidence that metabolome plays a pivotal role in GHD, but large-scale multicenter studies are warranted to validate the results.

MeSH

Growth, Hormones, Metabolomics, Therapeutics, Growth Hormone, Child