Journal Article Epublish 5 citations
PubMed: 39925345 DOI: 10.1016/j.ijcrp.2025.200371
Unraveling trends and disparities in acute myocardial infarction-related mortality among adult cancer patients: A nationwide CDC-WONDER analysis (1999-2020).
Int J Cardiol Cardiovasc Risk Prev 24:200371
Authors: Humza Saeed, Uzair Majeed, Minahil Iqbal, Sufyan Shahid, Anum Touseef Hussain, Hammad Ahmad Iftikhar, Momina Riaz Siddiqui, Iftikhar Ali Ch, Salman Khalid, Naeem Khan Tahirkheli
Affiliations
- Rawalpindi Medical University, Rawalpindi, Pakistan.
- Allama Iqbal Medical College, Lahore, Pakistan.
- Khawaja Muhammad Safdar Medical College, Sialkot, Pakistan.
- CMH Lahore Medical College, Lahore, Pakistan.
- South Oklahoma Heart Research, Oklahoma, United States.
- Oklahoma Heart Hospital, Oklahoma, United States.
Abstract
Background
Cancer patients are at an increased risk for the incidence and complications of acute myocardial infarction (AMI) due to shared risk factors and treatment-related adverse effects. Mortality trends for AMI-related deaths in adult cancer patients in the U.S. remain unexplored.
Methodology
This study used CDC WONDER data for death certificates from 1999 to 2020, identifying U.S. adults (≥25 years) with cancer (ICD-10: C00-D49) who died of AMI (ICD-10: I21) as the underlying cause. Age-adjusted mortality rates (AAMRs) and annual percent changes (APCs) were calculated and stratified by gender, age, race, and geographic location.
Results
Between 1999 and 2020, there were 109,462 AMI-related deaths in adult cancer patients. The AAMR decreased from 4.3 per 100,000 in 1999 to 1.4 in 2020. A significant decline occurred from 1999 to 2015 (APC: 6.65; 95 % CI: 6.95 to -6.40; p < 0.001), followed by a stable trend from 2015 to 2020 (APC: 1.36; 95 % CI: 2.69 to 0.91; p = 0.152). Men had higher AAMRs than women (3.5 vs. 1.5). AAMRs were highest in older adults (10.5) compared to middle-aged (0.7) and young adults (0.1). Racial disparities showed the highest AAMRs in non-Hispanic (NH) Black patients (2.7), followed by NH Whites (2.4), NH American Indian/Alaska Native (1.6), Hispanic/Latino (1.3), and NH Asian/Pacific Islander (1.1). Non-metropolitan areas had higher AAMRs than metropolitan areas (2.8 vs. 2.2).
Conclusions
This analysis highlights a significant decline in AMI-related mortality among cancer patients in the U.S., with persistent disparities by gender, age, race and geographical location.
MeSH
Mortality, Myocardial Infarction, Neoplasms, Centers For Disease Control And Prevention, U.S.